Brittany Kwait, Awais Paracha, Umar Durrani, Michael Attanasi, Fahad Hussain, Jervon Wright, Amanda Lee, Anthony Papale, Veena John
{"title":"肝卵黄囊肿瘤：表现、诊断和治疗的系统回顾。","authors":"Brittany Kwait, Awais Paracha, Umar Durrani, Michael Attanasi, Fahad Hussain, Jervon Wright, Amanda Lee, Anthony Papale, Veena John","doi":"10.1007/s12029-025-01250-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Primary hepatic yolk sac tumor (HYST) is a rare, extragonadal germ cell neoplasm that arises in hepatic tissue. This review aims to examine clinical features, diagnostic workup, and medical and surgical interventions in patients diagnosed with primary HYST.</p><p><strong>Methods: </strong>A literature search was performed using PubMed from 1950 to June 2024 using the filters English language and full text along with keywords \"Yolk sac tumor of the liver,\" \"Endodermal Sinus tumor of liver,\" \"Hepatic Yolk sac tumor,\" and \"Hepatic Endodermal sinus tumor.\"</p><p><strong>Results: </strong>Our results examined 20 patients ranging from age 15 months to 64 years. The cases included 14 female and 6 male patients. The most common presenting symptom was abdominal pain in adults and abdominal distention in children. Upon histologic evaluation, Schiller-Duval bodies were seen in the majority of examined tumors. Commonly noted markers included alpha fetal protein, cytokeratin AE1/AE3, alpha-1 anti-trypsin, placental alkaline phosphatase, SALL4, and periodic acid-Schiff. Treatment options included chemotherapy, surgery, transplant, and trans-arterial chemoembolization.</p><p><strong>Conclusions: </strong>In this review, we discuss clinical signs of primary HYST. We highlight the importance of Schiller-Duval bodies on histology, as well as new markers in an attempt to aid in making a diagnosis of HYST.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"131"},"PeriodicalIF":1.6000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hepatic Yolk Sac Tumor: A Systematic Review of Presentation, Diagnosis, and Treatment.\",\"authors\":\"Brittany Kwait, Awais Paracha, Umar Durrani, Michael Attanasi, Fahad Hussain, Jervon Wright, Amanda Lee, Anthony Papale, Veena John\",\"doi\":\"10.1007/s12029-025-01250-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Primary hepatic yolk sac tumor (HYST) is a rare, extragonadal germ cell neoplasm that arises in hepatic tissue. This review aims to examine clinical features, diagnostic workup, and medical and surgical interventions in patients diagnosed with primary HYST.</p><p><strong>Methods: </strong>A literature search was performed using PubMed from 1950 to June 2024 using the filters English language and full text along with keywords \\\"Yolk sac tumor of the liver,\\\" \\\"Endodermal Sinus tumor of liver,\\\" \\\"Hepatic Yolk sac tumor,\\\" and \\\"Hepatic Endodermal sinus tumor.\\\"</p><p><strong>Results: </strong>Our results examined 20 patients ranging from age 15 months to 64 years. The cases included 14 female and 6 male patients. The most common presenting symptom was abdominal pain in adults and abdominal distention in children. Upon histologic evaluation, Schiller-Duval bodies were seen in the majority of examined tumors. Commonly noted markers included alpha fetal protein, cytokeratin AE1/AE3, alpha-1 anti-trypsin, placental alkaline phosphatase, SALL4, and periodic acid-Schiff. Treatment options included chemotherapy, surgery, transplant, and trans-arterial chemoembolization.</p><p><strong>Conclusions: </strong>In this review, we discuss clinical signs of primary HYST. We highlight the importance of Schiller-Duval bodies on histology, as well as new markers in an attempt to aid in making a diagnosis of HYST.</p>\",\"PeriodicalId\":15895,\"journal\":{\"name\":\"Journal of Gastrointestinal Cancer\",\"volume\":\"56 1\",\"pages\":\"131\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Gastrointestinal Cancer\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12029-025-01250-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Gastrointestinal Cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12029-025-01250-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Hepatic Yolk Sac Tumor: A Systematic Review of Presentation, Diagnosis, and Treatment.
Purpose: Primary hepatic yolk sac tumor (HYST) is a rare, extragonadal germ cell neoplasm that arises in hepatic tissue. This review aims to examine clinical features, diagnostic workup, and medical and surgical interventions in patients diagnosed with primary HYST.
Methods: A literature search was performed using PubMed from 1950 to June 2024 using the filters English language and full text along with keywords "Yolk sac tumor of the liver," "Endodermal Sinus tumor of liver," "Hepatic Yolk sac tumor," and "Hepatic Endodermal sinus tumor."
Results: Our results examined 20 patients ranging from age 15 months to 64 years. The cases included 14 female and 6 male patients. The most common presenting symptom was abdominal pain in adults and abdominal distention in children. Upon histologic evaluation, Schiller-Duval bodies were seen in the majority of examined tumors. Commonly noted markers included alpha fetal protein, cytokeratin AE1/AE3, alpha-1 anti-trypsin, placental alkaline phosphatase, SALL4, and periodic acid-Schiff. Treatment options included chemotherapy, surgery, transplant, and trans-arterial chemoembolization.
Conclusions: In this review, we discuss clinical signs of primary HYST. We highlight the importance of Schiller-Duval bodies on histology, as well as new markers in an attempt to aid in making a diagnosis of HYST.
期刊介绍：
The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
