Ppm水平钯催化烯醇的区域选择性远芳基化。

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2025-06-03 DOI:10.1039/d5sc02745d

Chong Liu, Ling Wang, Haibo Ge

{"title":"Ppm水平钯催化烯醇的区域选择性远芳基化。","authors":"Chong Liu, Ling Wang, Haibo Ge","doi":"10.1039/d5sc02745d","DOIUrl":null,"url":null,"abstract":"Recent studies highlight the importance and application of parts per million (ppm) palladium concentration in catalytic reactions. Lowering catalyst loading minimizes costs, simplifies purification, and reduces metal contamination, making it highly attractive for pharmaceutical and fine chemical manufacturing. Here, we report a ppm level Pd-catalyzed remote arylation reaction of alkenols, achieving high efficiency, regioselectivity, and flexible carbonyl scaffold construction. Notably, this strategy exhibits excellent compatibility with styrene-derived substrates and has been successfully achieved on a gram scale, providing a solid foundation for potential large-scale applications.","PeriodicalId":9909,"journal":{"name":"Chemical Science","volume":" ","pages":""},"PeriodicalIF":7.6000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147037/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ppm level palladium catalyzed regioselective remote arylation of alkenyl alcohols.\",\"authors\":\"Chong Liu, Ling Wang, Haibo Ge\",\"doi\":\"10.1039/d5sc02745d\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recent studies highlight the importance and application of parts per million (ppm) palladium concentration in catalytic reactions. Lowering catalyst loading minimizes costs, simplifies purification, and reduces metal contamination, making it highly attractive for pharmaceutical and fine chemical manufacturing. Here, we report a ppm level Pd-catalyzed remote arylation reaction of alkenols, achieving high efficiency, regioselectivity, and flexible carbonyl scaffold construction. Notably, this strategy exhibits excellent compatibility with styrene-derived substrates and has been successfully achieved on a gram scale, providing a solid foundation for potential large-scale applications.\",\"PeriodicalId\":9909,\"journal\":{\"name\":\"Chemical Science\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.6000,\"publicationDate\":\"2025-06-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147037/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5sc02745d\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Science","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5sc02745d","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

近年来的研究强调了百万分之一（ppm）钯浓度在催化反应中的重要性和应用。降低催化剂负载可最大限度地降低成本，简化净化，减少金属污染，使其对制药和精细化工制造具有很高的吸引力。在这里，我们报道了一个ppm水平的pd催化的烯醇远程芳基化反应，实现了高效率、区域选择性和灵活的羰基支架结构。值得注意的是，该策略与苯乙烯基板具有良好的相容性，并已成功地在克尺度上实现，为潜在的大规模应用提供了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Ppm level palladium catalyzed regioselective remote arylation of alkenyl alcohols.

Recent studies highlight the importance and application of parts per million (ppm) palladium concentration in catalytic reactions. Lowering catalyst loading minimizes costs, simplifies purification, and reduces metal contamination, making it highly attractive for pharmaceutical and fine chemical manufacturing. Here, we report a ppm level Pd-catalyzed remote arylation reaction of alkenols, achieving high efficiency, regioselectivity, and flexible carbonyl scaffold construction. Notably, this strategy exhibits excellent compatibility with styrene-derived substrates and has been successfully achieved on a gram scale, providing a solid foundation for potential large-scale applications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.