探索小胶质细胞替代：从疾病模型到临床转化

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-06-09 DOI:10.1016/j.bbi.2025.06.011

Kai Zhou , Yafeng Wang , Yiran Xu , Yaodong Zhang , Changlian Zhu

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引用次数: 0

摘要

小胶质细胞是中枢神经系统（CNS）的常驻免疫细胞，在免疫监视、突触重塑和神经炎症反应中发挥关键作用。最近的兴趣集中在小胶质细胞替代疗法上，以更新小胶质细胞群，减轻神经炎症，并传递功能基因。本文综述了目前关于小胶质细胞替代疗法潜在应用的研究，重点介绍了采用不同消耗模型的临床前研究、替代小胶质细胞的来源及其对中枢神经系统疾病的影响。此外，挑战和注意事项的小胶质细胞替代疗法的临床翻译进行了讨论。总之，小胶质细胞替代疗法有望恢复中枢神经系统稳态和改善神经炎症，为中枢神经系统疾病的改善治疗提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploring microglial replacement: From disease models to clinical translation

Microglia, the resident immune cells of the central nervous system (CNS), play pivotal roles in immune surveillance, synaptic remodeling, and neuroinflammatory responses. Recent interest has focused on microglial replacement therapy to renew microglial populations, mitigate neuroinflammation, and deliver functional genes. This review synthesizes current research on the potential applications of microglial replacement therapy, highlighting preclinical studies employing diverse depletion models, the source of replaced microglia, and their impacts on CNS disorders. Moreover, challenges and considerations for the clinical translation of microglial replacement therapy are discussed. Overall, microglial replacement therapy holds promise for restoring CNS homeostasis and ameliorating neuroinflammation, offering new avenues for the development of disease-modifying treatments for CNS disorders.

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.