Wnt/β-连环蛋白介导的癌症信号通路：最新进展及其在癌症治疗中的应用

IF 33.9 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-06-10 DOI:10.1186/s12943-025-02363-1

Xiuzhu Wu, Haiying Que, Qingfang Li, Xiawei Wei

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引用次数: 0

摘要

Wnt/β-catenin信号通路是一个高度保守的信号通路，通过多种生物学过程，包括致癌转化、基因组不稳定、癌细胞增殖、干性、代谢、细胞死亡、免疫调节和转移，与癌症的发生密切相关。值得注意的是，它的激活在化疗、靶向治疗和免疫治疗的耐药中起着至关重要的作用。药物开发的最新进展已经确定了几种作用于该途径关键节点的靶向抑制剂，其中一些与免疫治疗剂联合使用时显示出协同效应。本文综述了Wnt/β-catenin通路在恶性肿瘤中的作用，强调了其在肿瘤起始、治疗抵抗和免疫调节中的多重作用。此外，我们总结了针对Wnt/β-catenin通路联合化疗、靶向治疗和免疫治疗的临床疗效。尽管临床发展仍处于相对早期的阶段，但Wnt/β-catenin信号的药理调节作为一种新的精准肿瘤学治疗模式提供了相当大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Wnt/β-catenin mediated signaling pathways in cancer: recent advances, and applications in cancer therapy

The Wnt/β-catenin signaling pathway is a highly conserved signaling pathway closely linked to cancer development through various biological processes, including oncogenic transformation, genomic instability, cancer cell proliferation, stemness, metabolism, cell death, immune regulation, and metastasis. Notably, its activation plays a crucial role in drug resistance to chemotherapy, targeted therapy and immunotherapy. Recent advances in drug development have identified several targeted inhibitors acting at key nodal points of this pathway, with some demonstrating synergistic efficacy when combined with immunotherapeutic agents. This review provides a comprehensive analysis of current understanding regarding the Wnt/β-catenin pathway in malignancy, emphasizing its multifaceted roles in tumor initiation, therapeutic resistance, and immune regulation. Additionally, we summarized the clinical performance of combination therapies targeting the Wnt/β-catenin pathway in conjunction with chemotherapy, targeted therapy, and immunotherapy. Although clinical development remains at a relatively early stage, pharmacological modulation of Wnt/β-catenin signaling offers considerable potential as a novel therapeutic paradigm in precision oncology.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

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