{"title":"1813例乳腺癌新辅助化疗患者保乳后切缘状态对同侧乳腺肿瘤复发的影响","authors":"Makoto Ishitobi, Atsushi Yoshida, Yuri Kimura, Yasuaki Sagara, Yuka Ono, Koji Takada, Yuko Takahashi, Takahiro Tsukioki, Mao Kimoto, Tomo Osako, Takehiko Sakai","doi":"10.1007/s12282-025-01732-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is no consensus regarding the optimal margin status among patients with breast cancer treated with neoadjuvant chemotherapy (NAC), breast-conserving surgery, and radiotherapy (breast-conserving treatment [BCT]).</p><p><strong>Methods: </strong>In total, 1813 patients with newly diagnosed stage 1-3 breast cancer who underwent BCT after NAC were evaluated to determine the impact of margin status on ipsilateral breast tumor recurrence (IBTR).</p><p><strong>Results: </strong>During a median follow-up period of 8.0 years (range 0.1-17.0 years), the 8-year IBTR-free survival rate was 95.9%. Patients with positive margins had significantly worse IBTR-free survival than those with negative margins (8-year IBTR-free survival rate: 87.6% vs. 96.2%, p = 0.010). Multivariate analysis showed that margin status was significantly associated with IBTR-free survival (hazard ratio: 3.1; 95% confidence interval 1.3-7.2; p = 0.0081).</p><p><strong>Conclusions: </strong>This multicenter retrospective study demonstrated that margin status is significantly associated with IBTR-free survival in patients who received NAC and BCT, consistent with findings in upfront-surgery cases.</p>","PeriodicalId":520574,"journal":{"name":"Breast cancer (Tokyo, Japan)","volume":" ","pages":"1044-1051"},"PeriodicalIF":2.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of margin status on ipsilateral breast tumor recurrence after breast-conserving treatment for patients with breast cancer who received neoadjuvant chemotherapy: a retrospective multi-institutional study of 1813 cases.\",\"authors\":\"Makoto Ishitobi, Atsushi Yoshida, Yuri Kimura, Yasuaki Sagara, Yuka Ono, Koji Takada, Yuko Takahashi, Takahiro Tsukioki, Mao Kimoto, Tomo Osako, Takehiko Sakai\",\"doi\":\"10.1007/s12282-025-01732-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is no consensus regarding the optimal margin status among patients with breast cancer treated with neoadjuvant chemotherapy (NAC), breast-conserving surgery, and radiotherapy (breast-conserving treatment [BCT]).</p><p><strong>Methods: </strong>In total, 1813 patients with newly diagnosed stage 1-3 breast cancer who underwent BCT after NAC were evaluated to determine the impact of margin status on ipsilateral breast tumor recurrence (IBTR).</p><p><strong>Results: </strong>During a median follow-up period of 8.0 years (range 0.1-17.0 years), the 8-year IBTR-free survival rate was 95.9%. Patients with positive margins had significantly worse IBTR-free survival than those with negative margins (8-year IBTR-free survival rate: 87.6% vs. 96.2%, p = 0.010). Multivariate analysis showed that margin status was significantly associated with IBTR-free survival (hazard ratio: 3.1; 95% confidence interval 1.3-7.2; p = 0.0081).</p><p><strong>Conclusions: </strong>This multicenter retrospective study demonstrated that margin status is significantly associated with IBTR-free survival in patients who received NAC and BCT, consistent with findings in upfront-surgery cases.</p>\",\"PeriodicalId\":520574,\"journal\":{\"name\":\"Breast cancer (Tokyo, Japan)\",\"volume\":\" \",\"pages\":\"1044-1051\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Breast cancer (Tokyo, Japan)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12282-025-01732-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast cancer (Tokyo, Japan)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12282-025-01732-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/9 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:对于接受新辅助化疗(NAC)、保乳手术和放疗(breast- conservation treatment [BCT])治疗的乳腺癌患者的最佳切缘状态尚无共识。方法:对1813例新诊断的1-3期乳腺癌NAC术后行BCT的患者进行评估,以确定切缘状态对同侧乳腺肿瘤复发(IBTR)的影响。结果:中位随访8.0年(0.1-17.0年),8年无ibtr生存率为95.9%。切缘阳性患者的无ibtr生存率明显低于切缘阴性患者(8年无ibtr生存率:87.6% vs. 96.2%, p = 0.010)。多因素分析显示,切缘状态与无ibtr生存显著相关(风险比:3.1;95%置信区间1.3-7.2;p = 0.0081)。结论:这项多中心回顾性研究表明,在接受NAC和BCT的患者中,切缘状态与无ibtr生存显著相关,与前期手术病例的发现一致。
Impact of margin status on ipsilateral breast tumor recurrence after breast-conserving treatment for patients with breast cancer who received neoadjuvant chemotherapy: a retrospective multi-institutional study of 1813 cases.
Background: There is no consensus regarding the optimal margin status among patients with breast cancer treated with neoadjuvant chemotherapy (NAC), breast-conserving surgery, and radiotherapy (breast-conserving treatment [BCT]).
Methods: In total, 1813 patients with newly diagnosed stage 1-3 breast cancer who underwent BCT after NAC were evaluated to determine the impact of margin status on ipsilateral breast tumor recurrence (IBTR).
Results: During a median follow-up period of 8.0 years (range 0.1-17.0 years), the 8-year IBTR-free survival rate was 95.9%. Patients with positive margins had significantly worse IBTR-free survival than those with negative margins (8-year IBTR-free survival rate: 87.6% vs. 96.2%, p = 0.010). Multivariate analysis showed that margin status was significantly associated with IBTR-free survival (hazard ratio: 3.1; 95% confidence interval 1.3-7.2; p = 0.0081).
Conclusions: This multicenter retrospective study demonstrated that margin status is significantly associated with IBTR-free survival in patients who received NAC and BCT, consistent with findings in upfront-surgery cases.