{"title":"自闭症谱系障碍的早期生物标志物揭晓——我们了解到了什么？","authors":"Daniel A Rossignol, Richard E Frye","doi":"10.1080/14737159.2025.2518143","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Autism Spectrum Disorder (ASD) affects 1 in 31 children in the U.S. highlighting the urgent need for early detection and intervention. Identifying reliable early biomarkers could revolutionize ASD diagnosis and improve outcomes by enabling timely therapeutic strategies.</p><p><strong>Areas covered: </strong>This review explores maternal, paternal, and environmental risk factors contributing to ASD, including immune dysregulation, metabolic conditions, toxicant exposures, and placental and amniotic factors. Biomarkers aid in identifying these factors.</p><p><strong>Expert opinion: </strong>Future research in maternal health and biomarkers is crucial for predicting ASD risk and developing personalized interventions. Advances in multi-omics, imaging, epigenetics, and AI-driven analysis can improve biomarker accuracy, enabling earlier detection and targeted therapies. However, challenges such as biomarker reliability and ASD heterogeneity must be addressed through large-scale validation studies and interdisciplinary collaboration to translate these discoveries into clinical practice effectively.</p>","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"1-6"},"PeriodicalIF":3.6000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Early biomarker for autism spectrum disorder unveiled - what are we learning?\",\"authors\":\"Daniel A Rossignol, Richard E Frye\",\"doi\":\"10.1080/14737159.2025.2518143\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Autism Spectrum Disorder (ASD) affects 1 in 31 children in the U.S. highlighting the urgent need for early detection and intervention. Identifying reliable early biomarkers could revolutionize ASD diagnosis and improve outcomes by enabling timely therapeutic strategies.</p><p><strong>Areas covered: </strong>This review explores maternal, paternal, and environmental risk factors contributing to ASD, including immune dysregulation, metabolic conditions, toxicant exposures, and placental and amniotic factors. Biomarkers aid in identifying these factors.</p><p><strong>Expert opinion: </strong>Future research in maternal health and biomarkers is crucial for predicting ASD risk and developing personalized interventions. Advances in multi-omics, imaging, epigenetics, and AI-driven analysis can improve biomarker accuracy, enabling earlier detection and targeted therapies. However, challenges such as biomarker reliability and ASD heterogeneity must be addressed through large-scale validation studies and interdisciplinary collaboration to translate these discoveries into clinical practice effectively.</p>\",\"PeriodicalId\":12113,\"journal\":{\"name\":\"Expert Review of Molecular Diagnostics\",\"volume\":\" \",\"pages\":\"1-6\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Review of Molecular Diagnostics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14737159.2025.2518143\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Molecular Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737159.2025.2518143","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
Early biomarker for autism spectrum disorder unveiled - what are we learning?
Introduction: Autism Spectrum Disorder (ASD) affects 1 in 31 children in the U.S. highlighting the urgent need for early detection and intervention. Identifying reliable early biomarkers could revolutionize ASD diagnosis and improve outcomes by enabling timely therapeutic strategies.
Areas covered: This review explores maternal, paternal, and environmental risk factors contributing to ASD, including immune dysregulation, metabolic conditions, toxicant exposures, and placental and amniotic factors. Biomarkers aid in identifying these factors.
Expert opinion: Future research in maternal health and biomarkers is crucial for predicting ASD risk and developing personalized interventions. Advances in multi-omics, imaging, epigenetics, and AI-driven analysis can improve biomarker accuracy, enabling earlier detection and targeted therapies. However, challenges such as biomarker reliability and ASD heterogeneity must be addressed through large-scale validation studies and interdisciplinary collaboration to translate these discoveries into clinical practice effectively.
期刊介绍：
Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting.
Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy.
Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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