Francesca Granata , Simona Leoni , Valeria Di Stefano , Anna Ludovica Fracanzani , Giovanna Graziadei
{"title":"1例红细胞原卟啉症患者接种SARS-CoV-2疫苗后肝脏复发","authors":"Francesca Granata , Simona Leoni , Valeria Di Stefano , Anna Ludovica Fracanzani , Giovanna Graziadei","doi":"10.1016/j.rare.2025.100097","DOIUrl":null,"url":null,"abstract":"<div><div>Erythropoietic protoporphyria (EPP) is a rare genetic disorder that can lead to liver complications in a subset of patients. We describe the case of a 36-year-old woman with genetically confirmed EPP who developed acute liver injury following the second and booster doses of the Pfizer-BioNTech SARS-Cov-2 vaccine. The clinical course included elevated liver enzymes and PPIX levels, thrombocytopenia, reactivation of autoimmune markers, and worsening liver stiffness. No other causes were identified. Statistical analysis confirmed significant biochemical changes post-vaccination. This case suggests a possible immune-mediated hepatic response triggered by vaccination in a genetically predisposed individual.</div></div>","PeriodicalId":101058,"journal":{"name":"Rare","volume":"3 ","pages":"Article 100097"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recurrent hepatic flares after SARS-CoV-2 vaccination in a patient with erythropoietic protoporphyria: A case report\",\"authors\":\"Francesca Granata , Simona Leoni , Valeria Di Stefano , Anna Ludovica Fracanzani , Giovanna Graziadei\",\"doi\":\"10.1016/j.rare.2025.100097\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Erythropoietic protoporphyria (EPP) is a rare genetic disorder that can lead to liver complications in a subset of patients. We describe the case of a 36-year-old woman with genetically confirmed EPP who developed acute liver injury following the second and booster doses of the Pfizer-BioNTech SARS-Cov-2 vaccine. The clinical course included elevated liver enzymes and PPIX levels, thrombocytopenia, reactivation of autoimmune markers, and worsening liver stiffness. No other causes were identified. Statistical analysis confirmed significant biochemical changes post-vaccination. This case suggests a possible immune-mediated hepatic response triggered by vaccination in a genetically predisposed individual.</div></div>\",\"PeriodicalId\":101058,\"journal\":{\"name\":\"Rare\",\"volume\":\"3 \",\"pages\":\"Article 100097\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Rare\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950008725000419\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rare","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950008725000419","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Recurrent hepatic flares after SARS-CoV-2 vaccination in a patient with erythropoietic protoporphyria: A case report
Erythropoietic protoporphyria (EPP) is a rare genetic disorder that can lead to liver complications in a subset of patients. We describe the case of a 36-year-old woman with genetically confirmed EPP who developed acute liver injury following the second and booster doses of the Pfizer-BioNTech SARS-Cov-2 vaccine. The clinical course included elevated liver enzymes and PPIX levels, thrombocytopenia, reactivation of autoimmune markers, and worsening liver stiffness. No other causes were identified. Statistical analysis confirmed significant biochemical changes post-vaccination. This case suggests a possible immune-mediated hepatic response triggered by vaccination in a genetically predisposed individual.
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