Senior Undergraduate Organic Chemistry Lab Course: Light-Driven Scaffold Editing

This advanced organic chemistry laboratory course is specifically designed for senior undergraduate students, focusing on molecular skeleton editing for new drug discovery. By using state-of-the-art light-driven scaffold editing, the course facilitates the conversion between six-membered nitrogen heterocycles and five-membered heterocycles, showcasing the significant advantages of molecular scaffold editing over traditional drug synthesis methods. The curriculum provides comprehensive practical training including designing control experiments, executing efficient flash column chromatography, and employing nuclear magnetic resonance (NMR) technology to analyze experimental outcomes. This training equips students with essential skills for modern synthesis techniques and addresses the educational gap in advanced drug synthesis methods and organic chemistry techniques, thereby laying a solid foundation for future academic or professional pursuits.