MicroRNA-146a-5p多态性与青少年抑郁症认知障碍的关系

IF 0.9 4区医学 Q4 GENETICS & HEREDITY

Molecular Syndromology Pub Date : 2025-05-01 Epub Date: 2024-11-29 DOI:10.1159/000542064

Chunping Xie, Qingting Hu, Chunhu Zhang, Kuancai Deng

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引用次数: 0

摘要

青少年抑郁症的发病率正在增加，并与严重的认知障碍有关。本文旨在探讨microRNA-146a-5p （miR-146a-5p）多态性与青少年抑郁症患者认知功能障碍的关系。方法：采用实时定量聚合酶链反应定量血清中miR-146a-5p。采用TaqMan SNP基因分型法检测miR-146a-5p基因多态性。采用χ2检验和logistic回归分析计算比值比和95%置信区间。结果：miR-146a rs2910164的基因分型显示，CC （OR = 0.443, 95% CI, 0.264-0.741, p = 0.002）和GC （OR = 0.445, 95% CI, 0.279-0.712, p = 0.001）基因型降低了青少年抑郁症认知功能障碍的风险。与rs2910164 G等位基因相比，C等位基因（OR = 0.794, 95% CI, 0.694-0.741, p = 0.001）是青少年抑郁症认知障碍的保护因素。logistic回归分析Rs2910164 （OR = 0.425, 95% CI = 0.273 ~ 0.662, p = 0.000）与青少年抑郁症认知功能障碍呈负相关。在CC和CG基因型携带者中，miR-146a-5p水平降低。结论：Rs2910164 C等位基因携带者在青少年抑郁症认知功能障碍中的风险较低，并可降低miR-146a-5p水平。

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Association of MicroRNA-146a-5p Polymorphism with Cognitive Impairment in Adolescents with Depressive Disorder.

Introduction: The incidence of depression in adolescents is increasing and is associated with severe cognitive impairment. This paper aimed to investigate the relationship between polymorphisms in microRNA-146a-5p (miR-146a-5p) and cognitive impairment in adolescent depression patients.

Methods: Quantitative real-time polymerase chain reaction was used to quantify miR-146a-5p in serum. Detection of miR-146a-5p gene polymorphism was performed by TaqMan SNP Genotyping Assay. Odds ratios and 95% confidence intervals (CIs) were calculated by chi-square test (χ²) and logistic regression analysis.

Results: Genotyping of miR-146a rs2910164 showed that CC (OR = 0.443, 95% CI, 0.264-0.741, p = 0.002) and GC (OR = 0.445, 95% CI, 0.279-0.712, p = 0.001) genotype reduced the risk of cognitive impairment in adolescent depression. The C allele (OR = 0.794, 95% CI, 0.694-0.741, p = 0.001) was a protective factor for cognitive impairment in adolescent depression compared to the rs2910164 G allele. Rs2910164 (OR = 0.425, 95% CI = 0.273-0.662, p = 0.000) showed a negative correlation with adolescents with cognitive impairment in depression by logistic regression analysis. The level of miR-146a-5p was decreased in carriers of the CC and CG genotypes.

Conclusion: Rs2910164 C allele carriers have a low risk of cognitive impairment in adolescent depression and could reduce miR-146a-5p level.

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来源期刊

Molecular Syndromology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

1.70

自引率

9.10%

发文量

期刊介绍： ''Molecular Syndromology'' publishes high-quality research articles, short reports and reviews on common and rare genetic syndromes, aiming to increase clinical understanding through molecular insights. Topics of particular interest are the molecular basis of genetic syndromes, genotype-phenotype correlation, natural history, strategies in disease management and novel therapeutic approaches based on molecular findings. Research on model systems is also welcome, especially when it is obviously relevant to human genetics. With high-quality reviews on current topics the journal aims to facilitate translation of research findings to a clinical setting while also stimulating further research on clinically relevant questions. The journal targets not only medical geneticists and basic biomedical researchers, but also clinicians dealing with genetic syndromes. With four Associate Editors from three continents and a broad international Editorial Board the journal welcomes submissions covering the latest research from around the world.