西非SIREN研究发现,低蔬菜摄入量使高血压患者中风的几率增加一倍。

IF 6.3 2区 医学 Q1 CLINICAL NEUROLOGY
Osahon Asowata, Ifeoluwa Bodunde, Akinkunmi Okekunle, Onoja M Akpa, David Kadan Danladi, Adekunle Gregory Fakunle, Morenikeji A Komolafe, Reginald Obiako, Kolawole Wahab, Joshua Akinyemi, Albert Akpalu, Olayinka Adebajo, Kelechukwu Uwanuruochi, Samuel Olowookere, Oyedunni Arulogun, Arti Singh, Paul Olowoyo, Oladotun Olalusi, Godwin Inalegwu Ogbole, Ganiyu Adeniyi Amusa, Sunday Adeniyi, Innocent Ijezie Chukwuonye, Okechukwu Ogah, Suleiman Y Isah, Phillip O Ibinaiye, Ayodipupo Oguntade, Eunice Olabinri, Adebolajo Adeyemo, Olayemi Balogun, Benedict Calys-Tagoe, Philip Adebayo, Lambert Appiah, Abiodun Ajose, Ayo Ogunmodede, Abiodun Adeoye, Vincent Shindali, Hamzat Bello, Atinuke M Agunloye, Ugochukwu Onyenonoro, Taiwo Olunuga, Richard Efidi, Oladimeji Adebayo, Musbahu Rabiu, Julius Adesina, Wisdom Oguike, Ayomide Owolabi, Fred Stephen Sarfo, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi
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引用次数: 0

摘要

背景:虽然高血压是一个主要的危险因素,但足够的蔬菜消费与较低的中风风险有关。然而,目前尚不清楚蔬菜摄入量低或不足是否会增加高血压患者中风的几率。这项研究评估了西非人低蔬菜摄入量和高血压与中风之间的相互作用。方法:在这项病例对照研究中,在尼日利亚和加纳的15家医院招募了3684例年龄≥18岁、年龄±5岁、性别和种族相匹配的脑卒中病例,同时招募了3684名健康对照。使用标准指南定义高血压,并通过食物频率问卷评估蔬菜摄入量。采用多变量调整条件logistic回归和相互作用模型,以95%置信区间(CI)估计优势比(OR)和低蔬菜摄入量(每周< 6份)与高血压的协同相互作用。归因比例(AP)、相互作用的相对超额风险(rei)和协同指数(SI)的估计双侧P < 0.05。结果:患者平均年龄59.0±14.9岁,女性3376例,占45.8%。卒中患者中,蔬菜摄入量低和高血压患病率分别为68.1%(2508例)和95.9%(3480例)。考虑到低蔬菜摄入量并伴有高血压,经多变量调整后卒中的几率为OR: 25.66 (95%CI: 16.65, 39.54), rei为13.40 (95%CI: 7.21, 19.59), AP为0.52 (95%CI: 0.44, 0.60), SI为2.19 (95%CI: 1.82, 2.63),相乘相互作用约为50%;1.51 (95%ci: 0.91, 2.49)。结论:在这一人群中,低蔬菜摄入量的高血压患者中风的几率增加一倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low Vegetable Consumption doubles the odds of Stroke among people with Hypertension: findings from the SIREN Study in West Africa.

Background: While hypertension is a primary risk factor, adequate vegetable consumption has been linked with a lower stroke risk. However, it is unclear whether low/inadequate vegetable consumption could aggravate the odds of stroke among people with hypertension. This study assessed the interaction of low vegetable consumption and hypertension with stroke among West Africans.

Methods: In this case-control study, 3684 stroke cases (aged ≥18 years) matched for age ±5 years, sex, and ethnicity, with 3684 healthy controls recruited across 15 hospital sites in Nigeria and Ghana. Hypertension was defined using standard guidelines, and vegetable consumption was assessed with a food frequency questionnaire. Multivariable-adjusted conditional logistic regression and interaction model were used to estimate the odds ratios (OR) with a 95% confidence interval (CI) and the synergistic interaction of both low vegetable consumption (< 6 servings per week) and hypertension. The attributable proportion (AP), relative excess risk due to interaction (RERI), and synergy index (SI) were estimated at a two-sided P < 0.05.

Results: Overall, the mean age was 59.0±14.9 years, and 45.8%(3376) were female. Among stroke cases, the prevalence of low vegetable consumption and hypertension was 68.1%(2508) and 95.9%(3480), respectively. The multivariable-adjusted odds of stroke, given low vegetable consumption with hypertension, was OR: 25.66 (95%CI: 16.65, 39.54) with a RERI of 13.40 (95%CI: 7.21, 19.59), AP of 0.52 (95%CI: 0.44, 0.60), SI of 2.19 (95%CI: 1.82, 2.63), and a multiplicative interaction of about 50%; 1.51 (95%CI: 0.91, 2.49).

Conclusion: The odds of stroke double with low vegetable consumption among people with hypertension in this population.

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来源期刊
International Journal of Stroke
International Journal of Stroke 医学-外周血管病
CiteScore
13.90
自引率
6.00%
发文量
132
审稿时长
6-12 weeks
期刊介绍: The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.
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