接受免疫治疗的实体瘤患者胃肠道（GI）免疫相关不良事件的缓解策略

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2025-06-06 DOI:10.1080/1750743X.2025.2516995

Angioletta Lasagna

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引用次数: 0

摘要

在过去的十年里，免疫疗法已经彻底改变了实体瘤的治疗算法。免疫检查点抑制剂（ICIs）对几种肿瘤类型显示出疗效，但它们可能有利于免疫相关不良事件（irAEs）的发展。急性呼吸道感染有时会危及生命。在这篇综述中，我们将简要分析主要的胃肠道毒性，并重点关注减轻irAEs的潜在策略，特别是通过改变肠道微生物群（GM）组成。最后，我们将简要介绍人工智能（AI）在预测ae中的潜在作用。

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Mitigation strategies for gastrointestinal (GI) immune-related adverse events for patients with solid tumors receiving immunotherapy.

Over the past decade, immunotherapy has revolutionized the treatment algorithm for solid tumors. Immune checkpoint inhibitors (ICIs) demonstrated efficacy against several tumor types, but they can favor the development of immune-related adverse events (irAEs). IrAEs can sometimes be life-threatening. In this review, we will briefly analyze the main gastro-intestinal toxicities and focus on potential strategies for mitigating irAEs, particularly through the modification of gut microbiota (GM) composition. Finally, we will briefly dwell on the potential role of artificial intelligence (AI) in the prediction of irAEs.

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.