Lianne Verbeek, Valeria Cortesi, Jip van Daelen, Thomas Klei, Nina A M Houben, Elise J Huisman, Pauline Snijder, Sophie J E Cramer, Irwin Reiss, Enrico Lopriore
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引用次数: 0
摘要
目的：确定延迟脐带夹紧3分钟后脐带血≥70 mL的脐带血（UCB）收集量的百分比。第二，将UCB容量与出生时胎龄、出生体重和性别联系起来。设计：我们对2023年11月至2024年12月期间通过剖腹产分娩的近期婴儿进行了一项多中心、前瞻性、可行性研究。UCB是在胎盘从子宫中取出后立即在子宫外收集的。结果：共尝试收集195例UCB。在11例（5.6%）中，由于脐带破裂或从子宫取出胎盘而导致胎盘受损而失败。其余184例UCB标本中位体积为72 mL （IQR为56-86 mL）。只有54%（100/184）患者的UCB体积达到≥70 mL的目标体积。我们发现UCB体积与出生体重呈正相关(R2=0.0813， F（1181)=16.02， p值2=0.0014，F(1181)=0.2553， p值=0.614）。结论：在大约一半的尝试中获得了足够的UCB体积（≥70 mL）。较高的出生体重与较大的UCB收集量相关。
Volume of umbilical cord blood collection in the era of delayed cord clamping: a multicentre, prospective, feasibility study.
Objectives: To determine the percentage of adequate umbilical cord blood (UCB) collections defined as ≥70 mL of UCB after delayed cord clamping for 3 min was applied. Second, to correlate the UCB volume to gestational age at birth, birth weight and sex.
Design: We conducted a multicentre, prospective, feasibility study in near-term infants delivered through caesarean section between November 2023 and December 2024. UCB was collected ex-utero, immediately after the placenta was removed from the womb.
Results: A total of 195 UCB collections were attempted. In 11 cases (5.6%), the attempt failed due to rupture of the umbilical cord or damaged placenta by removal of the placenta from the uterus. The median volume of the remaining 184 UCB collections was 72 mL (IQR 56-86 mL). In only 54% (100/184), the UCB volume reached the target volume of ≥70 mL. We found that UCB volume was positively associated with birth weight (R2=0.0813, F(1181)=16.02, p value <0.001) but not with gestational age at birth (R2=0.0014, F(1181)=0.2553, p value=0.614).
Conclusions: A sufficient UCB volume (≥70 mL) was obtained in approximately half of the attempts. A higher birth weight was associated with a larger volume of UCB collection.
期刊介绍：
Archives of Disease in Childhood is an international peer review journal that aims to keep paediatricians and others up to date with advances in the diagnosis and treatment of childhood diseases as well as advocacy issues such as child protection. It focuses on all aspects of child health and disease from the perinatal period (in the Fetal and Neonatal edition) through to adolescence. ADC includes original research reports, commentaries, reviews of clinical and policy issues, and evidence reports. Areas covered include: community child health, public health, epidemiology, acute paediatrics, advocacy, and ethics.
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