儿科银屑病与心血管疾病的关联：系统综述和荟萃分析

Q4 Medicine

Piel Pub Date : 2025-06-01 DOI:10.1016/j.piel.2024.09.009

Luis Humberto Manrique Rubio , Karen Tatiana Velandia Vargas , Juan Camilo Zuleta Trujillo , Adriana María Reyes Rivera , Tatiana Cardona Narváez , María Fernanda Hernández , Javier Villafane Barraza

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引用次数: 0

摘要

银屑病是一种炎症性、免疫介导的全身性疾病，主要影响皮肤，与成人心血管疾病的风险增加有关。然而，关于这种关联在儿科人群中的可用数据仍然有限。目的探讨小儿牛皮癣患者发生心血管疾病的风险。方法根据PRISMA 2020声明，使用PubMed/Medline、Scopus、Embase和Web of Science数据库进行系统评价和荟萃分析。11项研究被纳入质性回顾，10项研究被纳入元分析。研究分析了8,775名小儿牛皮癣患者和31,793名对照者的数据。结果相关心血管疾病为：代谢综合征OR 5.09 （95% CI 2.37;10.93）、高血压OR 4.80 （95% CI 2.59;8.86）、糖尿病OR 3.04 （95% CI 1.44;6.40）、肥胖OR 2.88 （95% CI 1.53;5.45）、血脂异常OR 2.32 （95% CI 1.85;2.91）。结论小儿银屑病与高血压、糖尿病、血脂异常、肥胖等代谢综合征相关，提示银屑病的促炎状态与心血管疾病的早期发展存在重要的相互作用。

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查看原文本刊更多论文

Asociación entre psoriasis y enfermedades cardiovasculares en pediatría: revisión sistemática y metaanálisis

Introduction

Psoriasis is an inflammatory, immune-mediated, systemic disease that primarily affects the skin and is associated with an increased risk of cardiovascular diseases in adults. However, the available data on this association in the pediatric population are still limited.

Objective

To identify the risk of cardiovascular diseases in the pediatric population diagnosed with psoriasis.

Methodology

A systematic review and meta-analysis were conducted using the PubMed/Medline, Scopus, Embase and Web of Science databases according to the PRISMA 2020 statement. Eleven studies were included in the qualitative review and ten studies in the meta-analysis. Data from 8,775 pediatric patients with psoriasis and 31,793 controls were analyzed.

Results

The associated cardiovascular diseases were: metabolic syndrome OR 5.09 (95% CI 2.37;10.93), hypertension OR 4.80 (95% CI 2.59;8.86), diabetes OR 3.04 (95% CI 1.44;6.40), obesity OR 2.88 (95% CI 1.53;5.45) and dyslipidemia OR 2.32 (95% CI 1.85;2.91).

Conclusions

Psoriasis in the pediatric population was significantly associated with various components of metabolic syndrome, such as hypertension, diabetes, dyslipidemia and obesity, suggesting an important interaction between the pro-inflammatory state of psoriasis and the early development of cardiovascular diseases.

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来源期刊

Piel Medicine-Dermatology

CiteScore

0.10

自引率

0.00%

发文量

179

审稿时长

47 days

期刊介绍： La mejor revista para incrementar eficazmente sus habilidades diagnósticas y clínicas en dermatología, por la alta calidad de sus imágenes e iconografías, por el prestigio de sus colaboradores y por la actualidad de sus temas. Una publicación de máxima utilidad práctica para Especialistas y Profesionales de Atención Primaria.