中枢神经系统弥散性和迁移性斯巴达病:脊髓和颅内合并累及1例报告及文献复习。

Surgical neurology international Pub Date : 2025-05-16 eCollection Date: 2025-01-01 DOI:10.25259/SNI_146_2025
Prasert Iampreechakul, Korrapakc Wangtanaphat, Chonlada Angsusing, Sunisa Hangsapruek, Punjama Lertbutsayanukul, Nitat Kiathirannon, Samasuk Thammachantha, Adisak Tanpun, Surasak Komonchan
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引用次数: 0

摘要

背景:中枢神经系统斯巴达病是一种极为罕见的由螺虫幼虫引起的寄生虫感染。它的迁移性质和非特异性临床表现往往导致误诊,提出重大的诊断和治疗挑战。虽然中枢神经系统受累通常影响大脑或脊髓,但同时累及两个区域的弥散性病例极为罕见。病例描述:我们报告一例34岁的女性,最初表现为进行性腰痛和麻痹。经手术切除和组织病理学证实,她被诊断为脊柱稀疏症。尽管术后恢复顺利,但3年后她出现了进行性头痛。磁共振成像显示颅内病变,随后的手术证实大池spargosis。脑外科手术和脑室腹腔分流放置一年后,患者出现进行性头痛并伴有意识不清。最初误诊为脑脓肿,不慎给予甲硝唑静脉治疗2个月,症状好转。然而,影像学检查显示广泛的中枢神经受累,包括幕上、幕下和上颈椎区域。此外,有明确的证据表明寄生虫通过筛板迁移到额叶,突出了中枢神经系统斯巴达病的播散性和迁移性。结论:本病例突出了中枢神经系统斯巴达病的诊断复杂性和播散性,强调了早期手术干预和组织病理学证实的重要性。甲硝唑的意外临床反应提高了其在症状调节中的辅助作用的可能性,尽管其抗寄生虫功效仍未得到证实。考虑到无症状传播和复发的风险,长期随访和连续影像学检查是必要的。临床医生应在流行地区保持对斯巴达病的高度怀疑指数,以提高诊断准确性和患者预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disseminated and migratory sparganosis in the central nervous system: A case report and literature review of combined spinal and intracranial involvement.

Background: Central nervous system (CNS) sparganosis is an exceptionally rare parasitic infection caused by the larvae of Spirometra species. Its migratory nature and nonspecific clinical presentation often lead to misdiagnosis, posing significant diagnostic and therapeutic challenges. While CNS involvement typically affects either the brain or spinal cord, disseminated cases involving both regions are exceedingly rare.

Case description: We report the case of a 34-year-old woman who initially presented with progressive low back pain and paraparesis. She was diagnosed with spinal sparganosis following surgical resection and histopathological confirmation. Despite an uneventful postoperative recovery, she developed progressive headaches 3 years later. Magnetic resonance imaging revealed intracranial lesions, and subsequent surgery confirmed sparganosis in the cisterna magna. One year after brain surgery and ventriculoperitoneal shunt placement, the patient experienced progressive headaches accompanied by confusion. Under the initial misdiagnosis of brain abscess, she was inadvertently treated with intravenous metronidazole for 2 months, resulting in symptomatic improvement. However, a review of imaging demonstrated extensive CNS involvement, including the supratentorial, infratentorial, and upper cervical regions. In addition, there was clear evidence of parasite migration through the cribriform plate into the frontal lobe, highlighting the disseminated and migratory nature of CNS sparganosis.

Conclusion: This case highlights the diagnostic complexity and disseminated nature of CNS sparganosis, underscoring the importance of early surgical intervention and histopathological confirmation. The unexpected clinical response to metronidazole raises the possibility of its adjunctive role in symptom modulation, although its antiparasitic efficacy remains unproven. Given the risk of asymptomatic dissemination and recurrence, long-term follow-up with serial imaging is essential. Clinicians should maintain a high index of suspicion for sparganosis in endemic regions to improve diagnostic accuracy and patient outcomes.

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