{"title":"在一项大型回顾性队列研究中，先前的肛门生殖器疱疹和人乳头瘤病毒感染与硬化地衣风险增加有关。","authors":"Amit Singal, Kaya L Curtis, Shari R Lipner","doi":"10.1097/JW9.0000000000000210","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Lichen sclerosus (LS) is an inflammatory mucocutaneous disorder typically affecting the anogenital region with unknown etiology. It is postulated that infectious etiologies could play a role in pathogenesis.</p><p><strong>Objective: </strong>Herein, we analyze for potential associations between LS and infectious agents.</p><p><strong>Methods: </strong>The TriNetX research network was utilized to compare prevalence of prior infections in patients with versus without LS and risk of LS in patients with versus without prior infections.</p><p><strong>Results: </strong>Patients with versus without LS had a higher prevalence of prior herpes simplex virus (HSV), human papillomavirus (HPV), gonorrhea, chlamydia, Lyme disease, hepatitis B virus, and hepatitis C virus diagnosis. Preceding infections with HSV and HPV were associated with increased risk of developing LS. Preceding vaccination for HPV was associated with decreased risk of LS.</p><p><strong>Limitations: </strong>We were limited to ICD-10 codes and their accuracy. We could not confirm LS histopathologically, separate genital and extragenital LS, or assess specific HPV types.</p><p><strong>Conclusion: </strong>Our study suggests that HSV and HPV infections may be potential LS risk factors.</p>","PeriodicalId":53478,"journal":{"name":"International Journal of Women''s Dermatology","volume":"11 2","pages":"e210"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136664/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prior anogenital herpes and human papillomavirus infections are associated with increased risk of lichen sclerosus in a large retrospective cohort study.\",\"authors\":\"Amit Singal, Kaya L Curtis, Shari R Lipner\",\"doi\":\"10.1097/JW9.0000000000000210\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Lichen sclerosus (LS) is an inflammatory mucocutaneous disorder typically affecting the anogenital region with unknown etiology. It is postulated that infectious etiologies could play a role in pathogenesis.</p><p><strong>Objective: </strong>Herein, we analyze for potential associations between LS and infectious agents.</p><p><strong>Methods: </strong>The TriNetX research network was utilized to compare prevalence of prior infections in patients with versus without LS and risk of LS in patients with versus without prior infections.</p><p><strong>Results: </strong>Patients with versus without LS had a higher prevalence of prior herpes simplex virus (HSV), human papillomavirus (HPV), gonorrhea, chlamydia, Lyme disease, hepatitis B virus, and hepatitis C virus diagnosis. Preceding infections with HSV and HPV were associated with increased risk of developing LS. Preceding vaccination for HPV was associated with decreased risk of LS.</p><p><strong>Limitations: </strong>We were limited to ICD-10 codes and their accuracy. We could not confirm LS histopathologically, separate genital and extragenital LS, or assess specific HPV types.</p><p><strong>Conclusion: </strong>Our study suggests that HSV and HPV infections may be potential LS risk factors.</p>\",\"PeriodicalId\":53478,\"journal\":{\"name\":\"International Journal of Women''s Dermatology\",\"volume\":\"11 2\",\"pages\":\"e210\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12136664/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Women''s Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/JW9.0000000000000210\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women''s Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JW9.0000000000000210","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Prior anogenital herpes and human papillomavirus infections are associated with increased risk of lichen sclerosus in a large retrospective cohort study.
Background: Lichen sclerosus (LS) is an inflammatory mucocutaneous disorder typically affecting the anogenital region with unknown etiology. It is postulated that infectious etiologies could play a role in pathogenesis.
Objective: Herein, we analyze for potential associations between LS and infectious agents.
Methods: The TriNetX research network was utilized to compare prevalence of prior infections in patients with versus without LS and risk of LS in patients with versus without prior infections.
Results: Patients with versus without LS had a higher prevalence of prior herpes simplex virus (HSV), human papillomavirus (HPV), gonorrhea, chlamydia, Lyme disease, hepatitis B virus, and hepatitis C virus diagnosis. Preceding infections with HSV and HPV were associated with increased risk of developing LS. Preceding vaccination for HPV was associated with decreased risk of LS.
Limitations: We were limited to ICD-10 codes and their accuracy. We could not confirm LS histopathologically, separate genital and extragenital LS, or assess specific HPV types.
Conclusion: Our study suggests that HSV and HPV infections may be potential LS risk factors.
期刊介绍：
The IJWD publishes articles pertaining to dermatologic medical, surgical and cosmetic issues faced by female patients and their families. We are interested in original research articles, review articles, unusual case reports, new treatments, clinical trials, education, mentorship and viewpoint articles. Articles dealing with ethical issues in dermatology and medical legal scenarios are also welcome.Very important articles will have accompanying editorials. Topics which our subsections editors look forward to welcoming include: Women’s Health Oncology, Surgery and Aesthetics Pediatric Dermatology Medical Dermatology Society.
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