乳酸化在癌症中的作用机制及应用。

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell and Bioscience Pub Date : 2025-06-04 DOI:10.1186/s13578-025-01415-9

Jiewen Wang, Mingjing Peng, Linda Oyang, Mengzhou Shen, Shizhen Li, Xianjie Jiang, Zongyao Ren, Qiu Peng, Xuemeng Xu, Shiming Tan, Longzheng Xia, Wenjuan Yang, Haofan Li, Nayiyuan Wu, Yanyan Tang, Jinguan Lin, Qianjin Liao, Yaqian Han, Yujuan Zhou

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引用次数: 0

摘要

乳酸是癌症代谢的重要产物，它创造了一个支持癌症生长的酸性环境，并作为乳酸化的底物。乳酸酰化是一种新发现的表观遗传修饰，在癌细胞信号转导、代谢重编程、免疫应答等功能中起着重要作用。本文综述了乳酸化的调控机制，综述了其在肿瘤中的作用，并重点介绍了其在肿瘤耐药和免疫治疗中的应用。这些见解旨在为靶向乳酸化在癌症治疗中提供新的途径。

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Mechanism and application of lactylation in cancers.

Lactate is a crucial product of cancer metabolism, creating an acidic environment that supports cancer growth and acts as a substrate for lactylation. Lactylation, a newly discovered epigenetic modification, plays a vital role in cancer cell signaling, metabolic reprogramming, immune response, and other functions. This review explores the regulation of lactylation, summarizes recent research on its role in cancers, and highlights its application in cancer drug resistance and immunotherapy. These insights aim to provide new avenues for targeting lactylation in cancer therapy.

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来源期刊

Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

10.70

自引率

0.00%

发文量

187

审稿时长

>12 weeks

期刊介绍： Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.