调节性T细胞在癌症中的免疫代谢。

IF 7.3 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Oncogene Pub Date : 2025-06-04 DOI:10.1038/s41388-025-03458-1

Jordy Saravia, Hongbo Chi

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引用次数: 0

摘要

调节性T细胞（Regulatory T, Treg）在维持免疫耐受和组织稳态中发挥关键作用，但也阻碍抗肿瘤免疫。最近的工作已经确定Treg细胞如何在肿瘤微环境（TME）中代谢适应，并且这些适应通常比效应T细胞提供功能优势。此外，TME中Treg细胞功能的增强可能导致当前免疫疗法，特别是免疫检查点阻断（ICB）的疗效有限。在这里，我们回顾了最近在理解肿瘤中Treg细胞异质性和功能机制方面的进展，特别关注细胞代谢作为Treg细胞在TME中茁壮成长并促进肿瘤发生的潜在因素。我们描述了细胞代谢和营养或代谢通讯如何在TME中塑造Treg细胞谱系的身份和功能。我们还讨论了ICB与Treg细胞代谢和功能之间的相互作用，并重点介绍了目前针对TME中Treg细胞代谢的策略。了解肿瘤内Treg细胞的代谢控制为发现新的或联合治疗癌症提供了极好的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immunometabolism of regulatory T cells in cancer

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Immunometabolism of regulatory T cells in cancer

Regulatory T (Treg) cells play critical roles in maintaining immune tolerance and tissue homeostasis, but impede anti-tumor immunity. Recent work has established how Treg cells metabolically adapt within the tumor microenvironment (TME), and these adaptations frequently provide a functional advantage over effector T cells. Further, enhanced Treg cell function in the TME may contribute to the limited efficacy of current immunotherapies, especially immune checkpoint blockade (ICB). Here, we review recent progress in understanding mechanisms of Treg cell heterogeneity and function in tumors, with a particular focus on cellular metabolism as an underlying factor by which Treg cells are uniquely poised to thrive in the TME and contribute to tumorigenesis. We describe how cellular metabolism and nutrient or metabolic communication shape Treg cell lineage identity and function in the TME. We also discuss the interplay between ICB and Treg cell metabolism and function, and highlight current strategies targeting Treg cell metabolism specifically in the TME. Understanding metabolic control of intratumoral Treg cells provides excellent opportunities to uncover new or combination therapies for cancer.

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来源期刊

Oncogene 医学-生化与分子生物学

CiteScore

15.30

自引率

1.20%

发文量

404

审稿时长

1 months

期刊介绍： Oncogene is dedicated to advancing our understanding of cancer processes through the publication of exceptional research. The journal seeks to disseminate work that challenges conventional theories and contributes to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers. Emphasis is placed on research shedding light on processes driving metastatic spread and providing crucial insights into cancer biology beyond existing knowledge. Areas covered include the cellular and molecular biology of cancer, resistance to cancer therapies, and the development of improved approaches to enhance survival. Oncogene spans the spectrum of cancer biology, from fundamental and theoretical work to translational, applied, and clinical research, including early and late Phase clinical trials, particularly those with biologic and translational endpoints.