Jenny Stenberg, Annette Lennerling, Helen Andersson, Maria K. Svensson
{"title":"肾脏捐赠者在捐献前后感知和测量的压力水平，一项纵向队列研究","authors":"Jenny Stenberg, Annette Lennerling, Helen Andersson, Maria K. Svensson","doi":"10.1111/ctr.70208","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Transplantation with a kidney from a living donor has superior long-term patient and graft survival compared to a kidney from a deceased donor. For a kidney donor, feelings of stress may exist at different stages of the donation process. The aim of the study was to evaluate living kidney donors’ perceived and measured stress levels before and after donation.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this prospective observational cohort study with longitudinal follow-up, kidney donors were invited to answer three self-rating questionnaires targeting stress, vital exhaustion, and depressive symptoms the day before and two and six months after kidney donation. At the same time points, blood and saliva samples of insulin, glucose, and cortisol were collected.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Analyses were based on data from seventy-five individuals, with a mean age 46.5 (11) years, 60% women. The kidney donors scored low in self-rating stress, exhaustion and depression both pre- and two and six months post-donation, and no correlations were established between self-reported measures and metabolic stress biomarkers. Post-donation, however, a gender difference emerged, with women reporting decreased vitality scores 32.1 (9.3) and 30.7 (11.6) at two and six months versus men reporting increased scores 35.8 (6.9) and 36.9 (7.1). Six months post-donation, women also reported more symptoms of depression than men, 12.2 (12.5) versus 6.4 (8.2) (<i>p</i> = 0.058).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Kidney donors’ self-reported and measured stress levels and depressive symptoms were low and did not change from pre-donation up to six months after donation. The low levels of subjective and objective stress reported by the donors support the limited risks associated with living kidney donation. However, six months post-donation, women reported more feelings of exhaustion and depression than did men. Practitioner points: (1) The low levels of subjective and objective stress reported by kidney donors support the limited risks associated with living kidney donation. (2) Because most kidney donors are women, the gender difference in perceived stress levels presented in this study is of clinical relevance. (3) A more structured psychosocial follow-up could enable the identification of individuals in need of more psychological follow-up post-donation.</p>\n </section>\n </div>","PeriodicalId":10467,"journal":{"name":"Clinical Transplantation","volume":"39 6","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ctr.70208","citationCount":"0","resultStr":"{\"title\":\"Kidney Donors' Perceived and Measured Stress Levels Before and After Donation, a Longitudinal Cohort Study\",\"authors\":\"Jenny Stenberg, Annette Lennerling, Helen Andersson, Maria K. Svensson\",\"doi\":\"10.1111/ctr.70208\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Transplantation with a kidney from a living donor has superior long-term patient and graft survival compared to a kidney from a deceased donor. For a kidney donor, feelings of stress may exist at different stages of the donation process. The aim of the study was to evaluate living kidney donors’ perceived and measured stress levels before and after donation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this prospective observational cohort study with longitudinal follow-up, kidney donors were invited to answer three self-rating questionnaires targeting stress, vital exhaustion, and depressive symptoms the day before and two and six months after kidney donation. At the same time points, blood and saliva samples of insulin, glucose, and cortisol were collected.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Analyses were based on data from seventy-five individuals, with a mean age 46.5 (11) years, 60% women. The kidney donors scored low in self-rating stress, exhaustion and depression both pre- and two and six months post-donation, and no correlations were established between self-reported measures and metabolic stress biomarkers. Post-donation, however, a gender difference emerged, with women reporting decreased vitality scores 32.1 (9.3) and 30.7 (11.6) at two and six months versus men reporting increased scores 35.8 (6.9) and 36.9 (7.1). Six months post-donation, women also reported more symptoms of depression than men, 12.2 (12.5) versus 6.4 (8.2) (<i>p</i> = 0.058).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Kidney donors’ self-reported and measured stress levels and depressive symptoms were low and did not change from pre-donation up to six months after donation. The low levels of subjective and objective stress reported by the donors support the limited risks associated with living kidney donation. However, six months post-donation, women reported more feelings of exhaustion and depression than did men. Practitioner points: (1) The low levels of subjective and objective stress reported by kidney donors support the limited risks associated with living kidney donation. (2) Because most kidney donors are women, the gender difference in perceived stress levels presented in this study is of clinical relevance. (3) A more structured psychosocial follow-up could enable the identification of individuals in need of more psychological follow-up post-donation.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10467,\"journal\":{\"name\":\"Clinical Transplantation\",\"volume\":\"39 6\",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ctr.70208\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70208\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Transplantation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ctr.70208","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Kidney Donors' Perceived and Measured Stress Levels Before and After Donation, a Longitudinal Cohort Study
Introduction
Transplantation with a kidney from a living donor has superior long-term patient and graft survival compared to a kidney from a deceased donor. For a kidney donor, feelings of stress may exist at different stages of the donation process. The aim of the study was to evaluate living kidney donors’ perceived and measured stress levels before and after donation.
Methods
In this prospective observational cohort study with longitudinal follow-up, kidney donors were invited to answer three self-rating questionnaires targeting stress, vital exhaustion, and depressive symptoms the day before and two and six months after kidney donation. At the same time points, blood and saliva samples of insulin, glucose, and cortisol were collected.
Results
Analyses were based on data from seventy-five individuals, with a mean age 46.5 (11) years, 60% women. The kidney donors scored low in self-rating stress, exhaustion and depression both pre- and two and six months post-donation, and no correlations were established between self-reported measures and metabolic stress biomarkers. Post-donation, however, a gender difference emerged, with women reporting decreased vitality scores 32.1 (9.3) and 30.7 (11.6) at two and six months versus men reporting increased scores 35.8 (6.9) and 36.9 (7.1). Six months post-donation, women also reported more symptoms of depression than men, 12.2 (12.5) versus 6.4 (8.2) (p = 0.058).
Conclusions
Kidney donors’ self-reported and measured stress levels and depressive symptoms were low and did not change from pre-donation up to six months after donation. The low levels of subjective and objective stress reported by the donors support the limited risks associated with living kidney donation. However, six months post-donation, women reported more feelings of exhaustion and depression than did men. Practitioner points: (1) The low levels of subjective and objective stress reported by kidney donors support the limited risks associated with living kidney donation. (2) Because most kidney donors are women, the gender difference in perceived stress levels presented in this study is of clinical relevance. (3) A more structured psychosocial follow-up could enable the identification of individuals in need of more psychological follow-up post-donation.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
