钯催化1,7-炔和羟胺级联合成三环喹啉-2(1H)-酮

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-06-05 DOI:10.1039/d5qo00697j

Jiajun Zhao, Xiaolong Wang, Yan Cao, Jun Ying

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引用次数: 0

摘要

研究了钯催化的1,7-炔与全氟烷基碘化物和羟胺的级联自由基环化和C-H胺化反应，用于快速构建三环喹啉-2(1H)- 1支架。反应进行顺利，得到了一系列高收率的三环喹啉-2(1H)- 1衍生物。值得注意的是，利用这种方法实现了各种药物的后期修饰。

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Palladium-Catalyzed Cascade Synthesis of Tricyclic Quinolin-2(1H)-ones from 1,7-Enynes and Hydroxylamines

A palladium-catalyzed cascade radical cyclization and C-H amination of 1,7-enynes with perfluoroalkyl iodides and hydroxylamine has been developed for the rapid construction of tricyclic quinolin-2(1H)-one scaffolds. The reaction proceeded smoothly to give a series of tricyclic quinolin-2(1H)-one derivatives in high yields. Notably, the late-stage modifications of various drugs were realized by using this method.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.