去铁胺在透析相关毛霉病中的作用:三例报告及文献复习。

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 1988-05-01

J R Boelaert, G F van Roost, P L Vergauwe, J J Verbanck, C de Vroey, M F Segaert

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引用次数: 0

摘要

我们报告3例维持性血液透析患者发展为暴发性、播散性和致死性毛霉病。通过显微镜和培养诊断1例，发现根足样根霉，另外2例通过死后显微镜诊断。这些患者接受去铁胺(DFO)治疗铝超载，没有铁超载。据报道，美国各中心有10例类似患者(只有1例例外)均接受了DFO。DFO沉淀毛霉病的机制尚不清楚。其解释可能是DFO对毛霉真菌起着铁载体的作用。肾功能衰竭患者血清中高水平的DFO可能加强了这一机制。来自25个佛兰德透析中心的调查提供的流行病学数据支持DFO治疗与透析相关毛霉病之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

The role of desferrioxamine in dialysis-associated mucormycosis: report of three cases and review of the literature.

We report 3 patients on maintenance hemodialysis who developed a fulminant, disseminated and fatal form of mucormycosis. The diagnosis was made by microscopy and culture in 1 case, yielding Rhizopus rhizopodiformis, and by post-mortem microscopy in the two other cases. These patients were receiving desferrioxamine (DFO) for aluminum overload and had no iron-overload. Ten similar patients, all (with only one possible exception) receiving DFO, have been reported from American centers. The mechanism by which DFO could precipitate mucormycosis is unsettled. The explanation might be that DFO acts as a siderophore to the Mucorales fungi. High serum levels of DFO in renal failure could enhance this mechanism. Epidemiological data, provided from an inquiry in 25 Flemish dialysis centers, support the association between DFO treatment and dialysis-associated mucormycosis.

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.