Kun Wang, Xianfeng Qiu, Pan Fan, Lu Mao, Yangzhi Ren
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The analysis revealed a large increase in the number of publications, particularly from 2019 to 2022. China, the USA, and Germany are the leading contributors, with notable contributions from key researchers such as Zhang Yang and Su Zhen. Research is primarily focused on miRNAs in primary sensory neurons, apoptosis, bioinformatics, spinal cord injury, and biomarkers, but there are challenges that need to be addressed, including a narrow focus on specific miRNAs, isolated pathways, limited standardized evidence, and an overreliance on animal models. Future trends suggest expanding regulatory networks, analyzing interconnected pathways, standardizing protocols, and conducting clinical and human trials. This study provides researchers and clinicians a comprehensive overview of current research and future prospects in the field. 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引用次数: 0
摘要
神经性疼痛是由神经损伤或功能障碍引起的,是一种复杂的慢性疾病,除了疼痛管理方面的进展外,治疗选择有限。MicroRNAs (miRNAs)是一种调节基因表达的小非编码rna,在疼痛调节中起着关键作用。本研究的目的是确定mirna相关神经性疼痛研究的研究热点和趋势,突出mirna作为诊断生物标志物和治疗靶点的潜力。对从Web of Science数据库检索的394篇文章(2009-2024)进行了文献计量分析,并使用Python来评估国家、机构和个人层面的合作,以及关键词爆发、引用趋势和聚类。分析显示,出版物数量大幅增加,特别是从2019年到2022年。中国、美国和德国是主要贡献者,张杨和苏震等关键研究人员做出了显著贡献。研究主要集中在初级感觉神经元、细胞凋亡、生物信息学、脊髓损伤和生物标志物中的mirna,但仍存在需要解决的挑战,包括对特定mirna的狭隘关注、孤立的途径、有限的标准化证据以及过度依赖动物模型。未来的趋势建议扩大监管网络,分析相互关联的途径,使协议标准化,并进行临床和人体试验。本研究为研究人员和临床医生提供了该领域当前研究和未来前景的全面概述。此外,本综述可以鼓励临床医生开发和改进基于mirna的治疗方法,为神经性疼痛提供新的诊断和治疗策略。
Knowledge Structure, Research Hotspots and Emerging Trends in the Role of miRNAs in Neuropathic Pain: a Quantitative Analysis Using Python.
Neuropathic pain, caused by nerve injury or dysfunction, is a complex and chronic condition with limited treatment options beyond advances in pain management. MicroRNAs (miRNAs), which are small noncoding RNAs that regulate gene expression, play a critical role in pain modulation. The aim of this study was to identify research hotspots and trends in miRNA-related neuropathic pain studies, highlighting the potential of miRNAs as diagnostic biomarkers and therapeutic targets. A bibliometric analysis of 394 articles (2009-2024) retrieved from the Web of Science database was conducted, and Python was used to evaluate collaborations at the country, institutional, and individual levels, as well as keyword bursts, citation trends, and clustering. The analysis revealed a large increase in the number of publications, particularly from 2019 to 2022. China, the USA, and Germany are the leading contributors, with notable contributions from key researchers such as Zhang Yang and Su Zhen. Research is primarily focused on miRNAs in primary sensory neurons, apoptosis, bioinformatics, spinal cord injury, and biomarkers, but there are challenges that need to be addressed, including a narrow focus on specific miRNAs, isolated pathways, limited standardized evidence, and an overreliance on animal models. Future trends suggest expanding regulatory networks, analyzing interconnected pathways, standardizing protocols, and conducting clinical and human trials. This study provides researchers and clinicians a comprehensive overview of current research and future prospects in the field. Furthermore, this review can encourage clinicians to develop and improve miRNA-based therapies, offering new diagnostic and therapeutic strategies for neuropathic pain.
期刊介绍:
Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.