钒-好还是坏-钒在中枢神经系统疾病中的作用，潜在的治疗靶点及其毒性

IF 2.9 3区医学 Q2 TOXICOLOGY

Toxicology letters Pub Date : 2025-06-02 DOI:10.1016/j.toxlet.2025.06.006

Katarzyna Stachowicz

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引用次数: 0

摘要

当我们看到灰尘颗粒漂浮在阳光下的空气中，我们没有意识到这些颗粒也含有钒。钒(V)是空气、土壤、水和食物中的微量元素。在生物体中，它主要以钒基（正离子）或钒酸盐（阴离子）的形式存在。钒在工业上有广泛的应用。此外，它的治疗潜力-特别是作为一种抗糖尿病药物-已被指出。然而，由于对其毒性和可能涉及认知障碍的假设担忧，其治疗用途存在争议。最近的研究重点是钒在治疗抑郁症或精神分裂症等疾病中的作用。这篇综述试图总结什么是已知的钒在代谢和认知障碍的背景下的潜力。它强调需要进一步研究其安全性、有效性和更广泛的治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vanadium – good or bad – The role of vanadium in the central nervous system disorders, potential therapeutic targets and its toxicity

When we see dust particles floating in the sunlit air, we do not realize that these particles also contain vanadium. Vanadium (V) is a trace element in air, soil, water, and food. In living organisms, it occurs mainly as vanadyl (cation) or vanadate (anion). Vanadium has a wide range of applications in the industry. In addition, its therapeutic potential - particularly as an anti-diabetic agent - has been indicated. However, its therapeutic use is controversial due to postulated concerns regarding its toxicity and possible involvement in cognitive disorders. Recent research is focusing on the role of vanadium in the treatment of conditions such as depression or schizophrenia. This review attempts to summarize what is known about the potential of vanadium in the context of both metabolic and cognitive disorders. It highlights the need for further research into its safety, efficacy, and wider therapeutic applications.

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