恶心、垂直凝视麻痹和过度睡眠：儿童aqp4抗体阳性NMOSD的不寻常表现

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY

Neuropediatrics Pub Date : 2025-06-11 DOI:10.1055/a-2625-0994

Tatjana A Oberholzer, Leonie Plastina, David Wille, Selma Sirin, Annette Hackenberg

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引用次数: 0

摘要

神经脊髓炎视谱障碍（NMOSD）是一种罕见的神经炎症性疾病，在白人人群中年发病率少于1例，发病年龄中位数为40岁。NMOSD通常表现为视神经炎和纵向广泛的横断面脊髓炎。各种脑干、小脑、间脑和半球症状也可能发生。早期诊断和治疗对于症状管理和预防复发和残疾至关重要。我们报告的情况下，青春期前的女孩，突出独特的临床和MRI特征和早期实质损害的风险。

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Nausea, Vertical Gaze Palsy, and Excessive Sleep: An Unusual Presentation of Pediatric AQP4-Antibody Positive Neuromyelitis Optica Spectrum Disorder.

Neuromyelitis optica spectrum disorder (NMOSD) is a rare neuroinflammatory disease with an annual incidence of less than 1 case in 1,000,000 in the White population and a median age of onset at 40 years. NMOSD usually presents with optic neuritis and longitudinally extensive transverse myelitis. Various brainstem, cerebellar, diencephalic, and hemispheric symptoms may also occur. Early diagnosis and treatment are crucial for symptom management and prevention of relapses and disability. We report the case of a prepubertal girl, highlighting unique clinical and magnetic resonance imaging features and the risk of early parenchymal damage.

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来源期刊

Neuropediatrics 医学-临床神经学

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： For key insights into today''s practice of pediatric neurology, Neuropediatrics is the worldwide journal of choice. Original articles, case reports and panel discussions are the distinctive features of a journal that always keeps abreast of current developments and trends - the reason it has developed into an internationally recognized forum for specialists throughout the world. Pediatricians, neurologists, neurosurgeons, and neurobiologists will find it essential reading.