在足月和早产中乳杆菌物种的效力和功能作用的基因组见解。

IF 3 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genomics Pub Date : 2025-05-31 DOI:10.1016/j.ygeno.2025.111063

Daizee Talukdar , Yodhaanjali Jinnenahalli Raju , Pradipta Jana , Komal Sharma , Prabhakar Babele , Akansha Kothidar , Taruna Ahrodia , Lekshmi Narendrakumar , K. Ramani Shyam , Upma Singh , Subhash Tanwar , Sachin Harle , Susmita Chaudhuri , Sreevatsan Raghavan , Nitya Wadhwa , Souvik Mukherjee , Shinjini Bhatnagar , Bhabatosh Das

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引用次数: 0

摘要

阴道微生物群通常由乳酸菌种类主导，通过防止感染在降低早产风险（PTB）方面发挥关键作用。在这项研究中，我们对从印度孕妇生殖道分离的133个乳杆菌基因组进行了测序。基因组分析确定了与病原体抗性和抗炎功能相关的基因。进一步对无细胞上清进行蛋白质组学分析，揭示了其抗菌特性，包括溶酶素和细菌素，而抗菌试验证实了其抑制生殖道病原体的能力。这些发现表明乳杆菌菌株可以抵抗有害微生物，潜在地降低感染风险和PTB。这个乳酸菌联盟有望开发旨在改善孕产妇健康的生物治疗药物。

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Genomic insights into the potency and functional roles of Lactobacillus species in term and preterm births

The vaginal microbiome, typically dominated by Lactobacillus species, plays a key role in reducing the risk of preterm birth (PTB) by protecting against infections. In this study, we sequenced 133 Lactobacillus genomes isolated from the reproductive tracts of pregnant Indian women. Genomic analysis identified genes linked to pathogen resistance and anti-inflammatory functions. Further proteome analysis of cell-free supernatant revealed antimicrobial properties, including lysin and bacteriocin, while antibacterial tests confirmed their ability to inhibit reproductive tract pathogens. These findings suggest that Lactobacillus strains protect against harmful microbes, potentially reducing infection risks and PTB. This Lactobacillus consortium holds promise for developing biotherapeutics aimed at improving maternal health.

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来源期刊

Genomics 生物-生物工程与应用微生物

CiteScore

9.60

自引率

2.30%

发文量

260

审稿时长

60 days

期刊介绍： Genomics is a forum for describing the development of genome-scale technologies and their application to all areas of biological investigation. As a journal that has evolved with the field that carries its name, Genomics focuses on the development and application of cutting-edge methods, addressing fundamental questions with potential interest to a wide audience. Our aim is to publish the highest quality research and to provide authors with rapid, fair and accurate review and publication of manuscripts falling within our scope.