癌变的本质和培养。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-06-03 DOI:10.1158/2159-8290.CD-25-0232

Emilia L Lim, James DeGregori

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引用次数: 0

摘要

在这期杂志中，Li和他的同事描述了小鼠两阶段模型中伴随皮肤癌发生的突变变化。他们证明，尽管诱变剂诱导的数千个突变可以持续几乎一生，但诱变剂诱导的起始必须遵循非诱变促进，这可能会改变组织景观，介导恶性表型的克隆选择。参见李等人的相关文章，第1115页。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Nature and Nurture of Carcinogenesis.

In this issue, Li and colleagues characterize the mutational changes that accompany skin carcinogenesis in the two-stage model in mice. They demonstrate that, despite inducing thousands of mutations that can persist for almost a lifetime, mutagen-induced initiation must be followed by non-mutagenic promotion, which presumably alters tissue landscapes to mediate clonal selection for malignant phenotypes. See related article by Li et al., p. 1115.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.