CAFs抑制NK细胞促进乳腺癌免疫抑制。

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-06-03 DOI:10.1158/2159-8290.CD-25-0512

Mara H Sherman

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引用次数: 0

摘要

虽然NK细胞经常浸润乳腺肿瘤微环境，但在这种情况下，它们经常被描述为功能失调，限制其抗肿瘤细胞毒性潜能的机制尚不清楚。在这一期中，Ben-Shmuel及其同事表明，乳腺癌相关成纤维细胞通过建立的配体-受体对与NK细胞相互作用，进而通过充当诱饵抑制NK细胞对癌细胞的细胞溶解潜能。参见Ben-Shmuel等人的相关文章，第1247页。

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CAFs Defang NK Cells to Promote Breast Cancer Immunosuppression.

Though NK cells often infiltrate the breast tumor microenvironment, they are frequently described as dysfunctional in this setting, and mechanisms limiting their antitumor cytotoxic potential are unclear. In this issue, Ben-Shmuel and colleagues show that breast cancer-associated fibroblasts interact with NK cells via established ligand-receptor pairs and in turn suppress NK-cell cytolytic potential against cancer cells by acting as decoys. See related article by Ben-Shmuel et al., p. 1247.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.