年龄和诊断后时间对骨髓增殖性肿瘤患者血栓形成风险的影响:一项基于全国登记的匹配队列研究。

IF 3.8 2区 医学 Q1 HEMATOLOGY
Nurgul Batyrbekova, Malin Hultcrantz, Anna Ravn Landtblom, Robert Szulkin, Paul W. Dickman, Therese M.-L. Andersson, Elisavet Syriopoulou
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引用次数: 0

摘要

血栓栓塞是骨髓增生性肿瘤(mpn)的主要并发症之一,特别是在诊断后的最初几年和随着年龄的增长。这项全国范围内匹配的队列研究使用瑞典登记来评估年龄或诊断后的时间对血栓形成风险更重要。我们确定了2001年至2021年间诊断的17 830例MPN患者,每个患者按性别、年龄和诊断年份与10个人群对照相匹配。诊断后首次血栓形成率和危险比(hr)使用灵活的参数生存模型,随着时间的推移,自诊断和达到年龄估计。所有年龄段的MPN患者的血栓形成率都明显较高,尤其是在诊断后的前2年,此后的血栓形成率仍高于年龄匹配的对照组。5年时,患者与对照组相比,任何血栓形成的HR(95%可信区间)在65岁时为1.8(1.7-1.9),70岁时为1.6(1.5-1.7),75岁及以上时为1.5(1.4-1.6)。达到年龄比诊断后的时间更重要,特别是在没有血栓的患者中。血栓发生率在诊断后的前2年内最高,其后与达到的年龄的关系大于与诊断后的时间的关系。这些发现强调了年龄和早期管理对于MPN患者优化临床护理的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of age and time since diagnosis on thrombosis risk in myeloproliferative neoplasm patients: A nationwide register-based matched cohort study

Impact of age and time since diagnosis on thrombosis risk in myeloproliferative neoplasm patients: A nationwide register-based matched cohort study

Thromboembolism is one of the major complications in myeloproliferative neoplasms (MPNs), especially in the initial years post-diagnosis and with increasing age. This nationwide matched cohort study used Swedish registers to assess whether attained age or time since diagnosis is more important for thrombosis risk. We identified 17 830 MPN patients diagnosed between 2001 and 2021, each matched with 10 population controls by sex, age and diagnosis year. Rates of first thrombosis post diagnosis and hazard ratios (HRs) were estimated using flexible parametric survival models over time since diagnosis and attained age. Thrombosis rates were significantly higher in MPN patients at all ages, especially in the first 2 years post-diagnosis, after which the rates remained higher than in age-matched controls. At 5 years, HR (95% confidence interval) for any thrombosis comparing patients to controls was 1.8 (1.7–1.9) at age 65, 1.6 (1.5–1.7) at age 70 and 1.5 (1.4–1.6) at age 75 and older. Attained age was more important than time since diagnosis, particularly in patients without prior thrombosis. Thrombosis rates were highest within the first 2 years post-diagnosis, then depended more on attained age than on time since diagnosis. These findings emphasize the importance of age and early management in MPN patients to optimize clinical care.

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来源期刊
CiteScore
8.60
自引率
4.60%
发文量
565
审稿时长
1 months
期刊介绍: The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
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