ir催化呋喃的friedel - crafts型不对称烯丙基化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-13 Epub Date: 2025-06-03 DOI:10.1021/acs.orglett.5c01389

Yuqi Zhang, Shixiang Sun, Mingyu Zhang, Martin G Banwell, Xinting Liang, Leijie Zhou

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引用次数: 0

摘要

虽然已经开发了许多方法来获取手性呋喃，但涉及直接使用呋喃底物的不对称催化转化尚未得到很好的探索。本文描述了第一个对映选择性friedel - crafts型烯丙基烷基化反应的例子，通过Ir催化，采用2-或3-取代衍生物与支链烯丙醇偶联，合成手性呋喃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ir-Catalyzed Friedel-Crafts-Type Asymmetric Allylation of Furans.

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Ir-Catalyzed Friedel-Crafts-Type Asymmetric Allylation of Furans.

Although many methods have been developed to access chiral furans, asymmetric catalytic transformations involving the direct use of furan substrates are less well explored. Herein, we describe the first examples of enantioselective Friedel-Crafts-type allylic alkylation reactions for the synthesis of chiral furans by employing 2- or 3-substituted derivatives and coupling these, through Ir catalysis, with branched allylic alcohols.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.