Effects of Laparoscopic Myomectomy on Myoglobin, Ischemic Modified Albumin, Total Antioxidant Capacity, Malondialdehyde, and Reactive Oxygen Species in Patients with Uterine Myoma.

Objective: To find out the effects of laparoscopic myomectomy on myoglobin (MYO), ischemic modified albumin (IMA), total antioxidant capacity (TAC), serum malondialdehyde (MDA), and reactive oxygen species (ROS) in patients with uterine myoma. Methods: According to different surgical treatment methods, 116 patients with uterine fibroids included from February 2022 to February 2023 were divided into two groups, including a laparotomy group and a laparoscope group. The former (n = 58) underwent open myomectomy, while the latter (n = 58) underwent laparoscopic myomectomy. The indexes of oxidative stress were compared before surgery and on the 1st and 3rd days after surgery. Intraoperative and postoperative recovery indicators and the incidence of postoperative complications were also compared. Results: Before surgery, there was no significant difference in oxidative stress level between the two groups (p > 0.05). The levels of MYO, IMA, MDA, and ROS decreased in the laparoscope group on the 1st and 3rd days after surgery. The data in the laparotomy group were lower than that in the laparoscope group, so the statistical difference appeared significantly (p < 0.05). The index of TAC in laparoscope group was higher than that in laparotomy group, so the statistical difference was significant (p < 0.05). Data such as the intraoperative time, intraoperative blood loss, the first time to get out of bed, the first time to exhaust, and the first time to eat in laparoscope group were lower than those in laparotomy group, suggesting that the statistical differences were significant (p < 0.05). Three months after surgery, the incidence of incision bleeding, emphysema, nerve damage, intestinal obstruction, and back pain in the laparoscopic group was lower than that in the cesarean section group. The incidence of incision bleeding and nerve damage in this group was 0, while the incidence of incision bleeding in the cesarean section group was as high as 8.62%, significantly higher than that in the laparoscope group (p < 0.05). Conclusions: It can reduce the oxidative stress of patients and shorten the recovery time of postoperative symptoms, so as to reduce the incidence of complications by means of laparoscopic myomectomy.