Profilin作为评估血液透析患者动脉粥样硬化的新生物标志物。

IF 0.5 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Kardiologiya Pub Date : 2025-06-02 DOI:10.18087/cardio.2025.5.n2605

Aydın Güçlü, Kağan Tur, Ömer Jaradat, Hacı Sütiçen, Muhammed Alpaslan, Zeynel Erbesler, Avşar Zerman

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引用次数: 0

摘要

目的：研究表明动脉粥样硬化与profin -1有显著相关性。然而，文献中没有关于血液透析（HD）患者profilin浓度的信息。本研究检测了profin -1与作为HD患者早期动脉粥样硬化标志物的颈动脉内膜-中膜厚度（CIMT）之间的关系。材料与方法：50例慢性HD患者和38例健康对照。采用高分辨率超声测量CIMT。结果：HD患者年龄较大，血中profin -1、C反应蛋白（CRP）、尿酸、甲状旁激素、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）浓度均高于对照组。在HD患者中，我们检查了影响CIMT的变量。CIMT与profilin-1呈显著相关（r = 0.637, p <0.01）， CIMT与年龄呈显著相关（r = 0.424, p = 0.002）。线性回归分析显示profin -1是颈动脉内膜-中膜厚度（CIMT）的重要独立预测因子。较高的profile -1水平与升高的CIMT值相关。结论：首次发现HD患者的profile -1浓度高于健康对照。此外，HD患者中profin -1与CIMT之间存在独立关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Profilin as a Novel Biomarker for Assessing Atherosclerosis in Hemodialysis Patients.

Aim: Studies have shown a significant correlation between atherosclerosis and profilin-1. However, there is no information in the literature on the concentration of profilin in hemodialysis (HD) patients. This research examined the association between profilin-1 and carotid intima-media thickness (CIMT), as a marker of early atherosclerosis in HD patients.

Material and methods: 50 chronic HD patients and 38 healthy, control patients were included in this study. CIMT was measured by high-resolution ultrasonography.

Results: The HD patients were older and had higher concentrations of profilin-1, C reactive protein (CRP), uric acid, parathormone, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) than the control patients. In the HD patients, variables impacting CIMT were examined. CIMT and profilin-1 were significantly correlated (r = 0.637, p <0.01), as were CIMT and age (r = 0.424, p = 0.002). Linear regression analysis revealed that profilin-1 is a significant and independent predictor of carotid intima-media thickness (CIMT). Higher profilin-1 levels were associated with increased CIMT values.

Conclusion: For the first time, it has been shown that HD patients had greater concentrations of profilin-1 than healthy controls. Also, an independent relationship between profilin-1 and CIMT in HD patients was demonstrated.

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来源期刊

Kardiologiya 医学-心血管系统

CiteScore

1.70

自引率

20.00%

发文量

审稿时长

3-8 weeks

期刊介绍： “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.