mRNA-1273 (Moderna) COVID-19疫苗后C3肾小球病变和急性肾损伤及其遗传分析

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2025-06-02 DOI:10.5414/CN111570

Ming-Yuan Victor Chao, Ching-Hsiu Peng, Fu-Pang Chang, Yi-Chun Wang

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引用次数: 0

摘要

COVID-19疫苗接种后肾小球疾病的出现，特别是mRNA疫苗，引起了科学界的极大兴趣。我们对一名51岁女性进行了遗传分析，该女性在第三次接种mRNA-1273 (Moderna) COVID-19疫苗后出现C3肾小球病变。通过全面的全基因组外显子组测序，我们在SLC12A3基因中发现了一个错义突变，以及其他遗传变异，这可能为疫苗相关肾小球疾病的分子机制提供见解。该病例强调了在遇到mRNA疫苗不良反应时探索遗传易感性的重要性，特别是那些影响补体途径和肾小球病变的不良反应。

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C3 glomerulopathy and acute kidney injury after mRNA-1273 (Moderna) COVID-19 vaccine and genetical analysis.

The emergence of glomerular diseases following COVID-19 vaccination, particularly with mRNA vaccines, has sparked significant interest in the scientific community. We present the genetic analysis of a case involving a 51-year-old female who developed C3 glomerulopathy following her 3^rd dose of the mRNA-1273 (Moderna) COVID-19 vaccine. Through comprehensive whole-genome exome sequencing, we identified a missense mutation in the SLC12A3 gene, along with other genetic variations, which may provide insights into the molecular mechanisms underpinning vaccine-associated glomerulopathies. This case underscores the importance of exploring genetic predispositions when encountering adverse reactions to mRNA vaccines, particularly those affecting the complement pathway and glomerulopathies.

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.