使用实验性硅基光子计数CT区分斑块和支架：与传统能量集成检测器CT的实验和临床比较

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-05-27 DOI:10.1016/j.ejrad.2025.112207

Emma Verelst , Hakån Almqvist , Staffan Holmin , Gert Van Gompel , Hans Koenraad Nieboer , Frans Vandenbergh , Johan De Mey , Dominic Crotty , Paul Deak , Nico Buls

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引用次数: 0

摘要

目的比较实验性硅基光子计数CT （Si-PCCT）与常规能量积分检测器CT （EIDCT）的斑块-支架界面。方法将人切除的支架动脉中央嵌入琼脂水模体中，在Si-PCCT和EIDCT上使用类似的扫描技术扫描，CT体积剂量指数（CTDIvol）为9 mGy。在150 mm和50 mm视场（150FOV, 50FOV）的等效设置下重建图像。采用5分Likert量表定量和定性评估斑块-支架区分、支架直径测量精度和开花。系统和fov之间的结果比较采用t检验和Wilcoxon sign -rank检验进行评估，读者间一致性采用类内相关性（ICC）进行评估。此外，我们还比较了一个临床颈动脉造影病例的EIDCT和Si-PCCT图像。结果si - pcct可提高斑块支架对比，减少血管开花(p <；与EIDCT相比，仅在50FOV时直径测量精度提高（p = 0.003）。150FOV Si-PCCT图像在支架外观（p = 0.001）、斑块外观(p <；0.001)，支架-斑块区分（p = 0.002）和开花（p = 0.001）。50FOV显示了类似的趋势。50FOV EIDCT图像提高了斑块-支架对比度（p = 0.046），减少了斑块盛开(p <；0.001)，改善支架外观（p = 0.025）。对于Si-PCCT，在50FOV下没有观察到任何改善。定量和定性ICC分别为0.93和0.96，实验结果反映在对患者病例的评价中。结论：本研究表明Si-PCCT具有提高图像对比度和空间分辨率的潜力，可以改善实验幻影和临床患者病例中斑块和支架的评估。

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Plaque and stent distinction using an experimental silicon-based photon-counting CT: An experimental and clinical comparison with conventional energy-integrated detector CT

Purpose

To compare plaque-stent interface using an experimental Silicon-based photon-counting CT (Si-PCCT) with a conventional energy-integrating detector CT (EIDCT).

Methods

A human-resected and stented artery was embedded centrally into an agar-water phantom and scanned in a Si-PCCT and an EIDCT using a similar scan technique targeting a CT volumetric dose index (CTDI_vol) of 9 mGy. Images were reconstructed using equivalent settings at 150 mm and 50 mm field-of-view (150FOV, 50FOV). Plaque-stent distinction, stent diameter measurement accuracy and blooming were quantitatively and qualitatively assessed using a 5-point Likert scale. Result comparisons between systems and FOVs were evaluated with a t-test and a Wilcoxon signed-rank test with inter-reader agreement assessed using intra-class correlation (ICC). Additionally, EIDCT and Si-PCCT images from a single clinical carotid angiography case were compared.

Results

Si-PCCT enabled improved plaque-stent contrast and reduced blooming (p < 0.001) at both FOVs, whereas diameter measurement accuracy was only improved at 50FOV (p = 0.003), compared to EIDCT. 150FOV Si-PCCT images were preferred over EIDCT images forstent appearance (p = 0.001), plaque appearance (p < 0.001), stent-plaque distinction (p = 0.002) and blooming (p = 0.001). 50FOV showed similar trends. 50FOV EIDCT images enabled improved plaque-stent contrast (p = 0.046), reduced blooming (p < 0.001), and improved stent appearance (p = 0.025). For Si-PCCT, no improvements were observed at 50FOV. Quantitative and qualitative ICC was 0.93 and 0.96, respectivelyThe experimental findings are reflected in the evaluation of the patient case.

Conclusion

This study demonstrates the potential of Si-PCCT to improve image contrast and spatial resolution, enabling improved assessment of plaque and stent in an experimental phantom and a clinical patient case.

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.