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{"title":"正常[18F]FE-PE2I PET在异常[123I]FP-CIT SPECT后持续诊断不确定患者中的应用。","authors":"Michiel Dhadamus, Aline Delva, Wies Deckers, Wim Vandenberghe, Koen Van Laere","doi":"10.1002/mds.30255","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In some patients with parkinsonism and abnormal dopamine transporter (DAT) imaging using [<sup>123</sup>I]FP-CIT single-photon emission computed tomography (SPECT), subsequent clinical evolution does not fit well with a neurodegenerative diagnosis.</p><p><strong>Objective: </strong>The objective was to analyze the results of positron emission tomography (PET) with the recently developed DAT radioligand [<sup>18</sup>F]FE-PE2I in patients with persistent diagnostic uncertainty despite an abnormal previous [<sup>123</sup>I]FP-CIT SPECT scan.</p><p><strong>Methods: </strong>This retrospective study included 19 patients with suspected parkinsonism and persistent diagnostic uncertainty after visually abnormal [<sup>123</sup>I]FP-CIT SPECT who subsequently underwent [<sup>18</sup>F]FE-PE2I PET (time between the two scans: 3.7 ± 2.2 years). Concordance between [<sup>123</sup>I]FP-CIT SPECT and [<sup>18</sup>F]FE-PE2I PET was determined after either purely visual assessment or semiquantitative analysis.</p><p><strong>Results: </strong>In 74% of cases with visually abnormal [<sup>123</sup>I]FP-CIT SPECT, [<sup>18</sup>F]FE-PE2I PET was visually normal. After semiquantitative analysis, 63% of cases with abnormal [<sup>123</sup>I]FP-CIT SPECT had normal [<sup>18</sup>F]FE-PE2I PET.</p><p><strong>Conclusions: </strong>[<sup>18</sup>F]FE-PE2I PET is normal in the majority of cases, with persistent diagnostic uncertainty after abnormal [<sup>123</sup>I]FP-CIT SPECT. © 2025 International Parkinson and Movement Disorder Society.</p>","PeriodicalId":520713,"journal":{"name":"Movement disorders : official journal of the Movement Disorder Society","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Normal [<sup>18</sup>F]FE-PE2I PET in Patients with Persistent Diagnostic Uncertainty after Abnormal [<sup>123</sup>I]FP-CIT SPECT.\",\"authors\":\"Michiel Dhadamus, Aline Delva, Wies Deckers, Wim Vandenberghe, Koen Van Laere\",\"doi\":\"10.1002/mds.30255\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In some patients with parkinsonism and abnormal dopamine transporter (DAT) imaging using [<sup>123</sup>I]FP-CIT single-photon emission computed tomography (SPECT), subsequent clinical evolution does not fit well with a neurodegenerative diagnosis.</p><p><strong>Objective: </strong>The objective was to analyze the results of positron emission tomography (PET) with the recently developed DAT radioligand [<sup>18</sup>F]FE-PE2I in patients with persistent diagnostic uncertainty despite an abnormal previous [<sup>123</sup>I]FP-CIT SPECT scan.</p><p><strong>Methods: </strong>This retrospective study included 19 patients with suspected parkinsonism and persistent diagnostic uncertainty after visually abnormal [<sup>123</sup>I]FP-CIT SPECT who subsequently underwent [<sup>18</sup>F]FE-PE2I PET (time between the two scans: 3.7 ± 2.2 years). Concordance between [<sup>123</sup>I]FP-CIT SPECT and [<sup>18</sup>F]FE-PE2I PET was determined after either purely visual assessment or semiquantitative analysis.</p><p><strong>Results: </strong>In 74% of cases with visually abnormal [<sup>123</sup>I]FP-CIT SPECT, [<sup>18</sup>F]FE-PE2I PET was visually normal. After semiquantitative analysis, 63% of cases with abnormal [<sup>123</sup>I]FP-CIT SPECT had normal [<sup>18</sup>F]FE-PE2I PET.</p><p><strong>Conclusions: </strong>[<sup>18</sup>F]FE-PE2I PET is normal in the majority of cases, with persistent diagnostic uncertainty after abnormal [<sup>123</sup>I]FP-CIT SPECT. © 2025 International Parkinson and Movement Disorder Society.</p>\",\"PeriodicalId\":520713,\"journal\":{\"name\":\"Movement disorders : official journal of the Movement Disorder Society\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Movement disorders : official journal of the Movement Disorder Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/mds.30255\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement disorders : official journal of the Movement Disorder Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/mds.30255","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Normal [18 F]FE-PE2I PET in Patients with Persistent Diagnostic Uncertainty after Abnormal [123 I]FP-CIT SPECT.
Background: In some patients with parkinsonism and abnormal dopamine transporter (DAT) imaging using [123 I]FP-CIT single-photon emission computed tomography (SPECT), subsequent clinical evolution does not fit well with a neurodegenerative diagnosis.
Objective: The objective was to analyze the results of positron emission tomography (PET) with the recently developed DAT radioligand [18 F]FE-PE2I in patients with persistent diagnostic uncertainty despite an abnormal previous [123 I]FP-CIT SPECT scan.
Methods: This retrospective study included 19 patients with suspected parkinsonism and persistent diagnostic uncertainty after visually abnormal [123 I]FP-CIT SPECT who subsequently underwent [18 F]FE-PE2I PET (time between the two scans: 3.7 ± 2.2 years). Concordance between [123 I]FP-CIT SPECT and [18 F]FE-PE2I PET was determined after either purely visual assessment or semiquantitative analysis.
Results: In 74% of cases with visually abnormal [123 I]FP-CIT SPECT, [18 F]FE-PE2I PET was visually normal. After semiquantitative analysis, 63% of cases with abnormal [123 I]FP-CIT SPECT had normal [18 F]FE-PE2I PET.
Conclusions: [18 F]FE-PE2I PET is normal in the majority of cases, with persistent diagnostic uncertainty after abnormal [123 I]FP-CIT SPECT. © 2025 International Parkinson and Movement Disorder Society.
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