预先存在的ω -3脂肪酸血清水平对院外心脏骤停后结局的影响：一项全面调查

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-05-28 DOI:10.1016/j.lfs.2025.123770

J. Grabert , G. Mohsen , C. Diepenseifen , U. Heister , M. Breil , M. Rohner , I. Graeff , J. Kappler , K. Gutbrod , P. Dörmann , J.C. Schewe , A. Kunsorg , A. Mayr , A. Stroemer , C. Stoppe , S. Zimmer , U. Hoffmann , G.D. Duerr , M. Wittmann , M. Velten

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引用次数: 0

摘要

院外心脏骤停（OHCA）仍然是一个生存率持续较低的医学挑战。Omega-3多不饱和脂肪酸（PUFAs）通过其抗炎和抗氧化作用赋予心脏和神经保护作用。这项前瞻性多中心研究旨在评估预先存在的PUFA血清水平对OHCA生存和神经预后的影响。方法：OHCA患者在恢复自然循环（ROSC）后立即采血，分析二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）血清水平。单因素和多因素分析纳入了人口统计学和复苏数据。在ohca后1、6、12和24 个月进行随访评估。结果：OHCA存活患者在1 个月和12 个月时ROSC后DHA水平显著升高（p = 0.01和p = 0.02）。同样，在所有随访时间点，ROSC后幸存者的EPA水平始终较高（1 个月：p = 0.04,6 个月：p = 0.03,12 个月：p ）。结论：本研究表明OHCA期间预先存在的PUFA血清水平与ROSC后的长期预后之间存在显著关联，突出了它们潜在的心脏和神经保护作用。这些发现强调了进一步研究在复苏领域潜在的治疗应用的必要性。

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The impact of preexisting omega-3 fatty acid serum levels on outcomes following out-of-hospital cardiac arrest: A comprehensive investigation

Background

Out-of-hospital cardiac arrest (OHCA) remains a medical challenge with persistently low survival rates. Omega-3 polyunsaturated fatty acids (PUFAs) confer cardiac and neuroprotection trough their anti-inflammatory and anti-oxidative effects. This prospective multicenter study aimed to evaluate the impact of pre-existing PUFA serum levels on OHCA survival and neurological outcome.

Methods

Blood samples were collected from OHCA patients immediately following the return of spontaneous circulation (ROSC) for the analysis of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) serum levels. Univariate and multivariate analyses incorporated demographic and resuscitation data. Follow-up assessments were conducted at 1, 6, 12 and 24 months post-OHCA.

Results

DHA levels after ROSC were significantly higher in patients who survived OHCA at 1 month and 12 months (p = 0.01 and p = 0.02, respectively). Similarly, EPA levels after ROSC were consistently higher in survivors across all follow-up time points (1 month: p = 0.04, 6 months: p = 0.03, 12 months: p < 0.001, 24 months: p = 0.03) compared to deceased patients at the corresponding time points. Multivariate analysis identified younger age (p = 0.03, OR 1.1), shorter no-flow time (p = 0.02, OR 1.3) and shorter cardiopulmonary resuscitation (CPR) duration (p = 0.02, OR 1.1) as strong predictors of survival following OHCA (numbers exemplarily for 12 months survival). Furthermore, the 77 % of survivors exhibited favorable neurological outcomes at 12 months post-OHCA.

Conclusion

This study demonstrates a significant association between preexisting PUFA serum levels during OHCA and long-term outcomes following ROSC, highlighting their potential cardio- and neuroprotective roles. These findings underscore the need for further research to investigate potential therapeutic applications in the field of resuscitation.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.