采用和不采用骨髓浓缩物进行髋臼唇修复术后的5年功能结果。

IF 4.3 1区 医学 Q1 ORTHOPEDICS
Scott D Martin, Kieran S Dowley, Bilal S Siddiq, Stephen M Gillinov, Jonathan S Lee, Nathan J Cherian, Christopher T Eberlin, Michael P Kucharik, Michael C Dean
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引用次数: 0

摘要

背景:在髋关节镜检查时骨髓浓缩物(BMAC)增强是一种潜在的解决方案,可以改善伴有髋臼唇撕裂的软骨损伤患者的功能结局;然而,随访功能评分至今未超过24个月。因此,本研究比较了关节镜下唇部修复术中采用或不采用BMAC增强术治疗软骨损伤患者的最低5年预后。方法:这是一项前瞻性队列研究,分析由单一外科医生进行髋臼唇修复的患者。根据BMAC是否与关节镜下唇部修复术联合使用,将患者分为BMAC组和对照组。人口统计学和术中变量,包括关节关节破裂和关节软骨损伤,在队列之间进行比较,以及患者在入组时和术后3、6、12、24和60个月报告的结果测量(PROMs)。结果:81例髋关节纳入分析:BMAC组39例(38例),对照组42例(39例)。单变量分析表明,两组之间的基线特征相似,包括体重指数、Tönnis角、外侧中心边缘角(LCEA)和α角(p < 0.05)。接受BMAC治疗的患者和对照组患者在入组和12个月随访期间报告了相似的PROMs。在24个月的随访中,接受BMAC治疗的患者在改良Harris髋关节评分(mHHS) (p = 0.004)、国际髋关节结局工具-33 (iHOT-33) (p = 0.012)和髋关节结局评分-日常生活活动(HOS-ADL) (p = 0.008)方面的得分均显著提高。这一趋势持续了一段时间,BMAC队列在60个月时mHHS (p < 0.001)、iHOT-33 (p = 0.006)和髋关节结局评分-运动亚量表(HOS-SS) (p = 0.012)得分显著较高。结论:与未接受BMAC修复的患者相比,接受BMAC增强髋臼唇修复的患者报告了更大的功能改善。这些差异通常在手术后24个月才变得明显,然后在60个月的随访中逐渐增加。这些发现是BMAC髋关节镜术后报道的第一个中期结果,因此表明在延长随访中有良好的效果。证据等级:治疗性III级。有关证据水平的完整描述,请参见作者说明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Five-Year Functional Outcomes After Acetabular Labral Repair with and without Bone Marrow Aspirate Concentrate.

Background: Bone marrow aspirate concentrate (BMAC) augmentation at the time of hip arthroscopy is a potential solution to improve functional outcomes in patients with cartilage damage concomitant with acetabular labral tearing; however, follow-up functional scores to date have not exceeded 24 months. Therefore, the present study compares minimum 5-year outcomes in patients treated with or without BMAC augmentation to address chondral damage during arthroscopic labral repair.

Methods: This was a prospective cohort study analyzing patients who underwent acetabular labral repair performed by a single surgeon. Patients were stratified into either the BMAC cohort or the control cohort depending on whether BMAC was utilized in conjunction with arthroscopic labral repair. Demographic and intraoperative variables, including chondrolabral junction breakdown and articular cartilage damage, were compared between cohorts, as were patient-reported outcome measures (PROMs) at enrollment and at 3, 6, 12, 24, and 60 months postoperatively.

Results: Eighty-one hips were included for analysis: 39 (38 patients) in the BMAC cohort and 42 (39 patients) in the control cohort. Univariate analyses demonstrated similar baseline characteristics between groups, including body mass index, Tönnis angle, lateral center-edge angle (LCEA), and alpha angle (p > 0.05 for each). Patients treated with BMAC and patients in the control group reported similar PROMs between enrollment and the 12-month follow-up. By the 24-month follow-up, patients treated with BMAC reported significantly higher scores for the modified Harris hip score (mHHS) (p = 0.004), the International Hip Outcome Tool-33 (iHOT-33) (p = 0.012), and the Hip Outcome Score-Activities of Daily Living (HOS-ADL) (p = 0.008). This trend persisted over time, with the BMAC cohort demonstrating significantly higher scores for the mHHS (p < 0.001), iHOT-33 (p = 0.006), and the Hip Outcome Score-Sports Subscale (HOS-SS) (p = 0.012) at 60 months.

Conclusions: Patients undergoing acetabular labral repair with BMAC augmentation reported significantly greater functional improvements compared with patients undergoing repair without BMAC. These differences generally did not become significant until 24 months after surgery, at which point they increased in magnitude until the 60-month follow-up. These findings, the first intermediate-term outcomes reported following hip arthroscopy with BMAC, therefore suggest favorable benefit at an extended follow-up.

Level of evidence: Therapeutic Level III . See Instructions for Authors for a complete description of levels of evidence.

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来源期刊
CiteScore
8.90
自引率
7.50%
发文量
660
审稿时长
1 months
期刊介绍: The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, The Journal publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal.
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