免疫组织化学在转移性乳腺癌诊断中的应用进展。

IF 2.6 2区医学 Q2 PATHOLOGY

Human pathology Pub Date : 2025-08-01 DOI:10.1016/j.humpath.2025.105821

Hongxia Sun, Aysegul A. Sahin, Qingqing Ding

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引用次数: 0

摘要

准确诊断转移性乳腺癌对有效的临床治疗至关重要。免疫组织化学在确认或排除乳腺起源方面起着关键作用。在这篇综述中，我们讨论了传统的和新发现的乳腺癌标志物，特别关注与TRPS1相关的研究，并分享了我们在应用该标志物方面的经验。此外，我们还探讨了使用这些标记来区分转移性乳腺癌和其他来源的恶性肿瘤的挑战。

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Updates on utility of immunohistochemistry in diagnosis of metastatic breast cancer

Accurate diagnosis of metastatic breast carcinoma is essential for effective clinical management. Immunohistochemistry plays a pivotal role in confirming or excluding a breast origin. In this review, we discuss both traditional and newly identified breast cancer markers, with a particular focus on studies related to TRPS1, and share our experience in applying this marker. Additionally, we explore the challenges associated with using these markers to differentiate metastatic breast cancer from malignancies of other origins.

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来源期刊

Human pathology 医学-病理学

CiteScore

5.30

自引率

6.10%

发文量

206

审稿时长

21 days

期刊介绍： Human Pathology is designed to bring information of clinicopathologic significance to human disease to the laboratory and clinical physician. It presents information drawn from morphologic and clinical laboratory studies with direct relevance to the understanding of human diseases. Papers published concern morphologic and clinicopathologic observations, reviews of diseases, analyses of problems in pathology, significant collections of case material and advances in concepts or techniques of value in the analysis and diagnosis of disease. Theoretical and experimental pathology and molecular biology pertinent to human disease are included. This critical journal is well illustrated with exceptional reproductions of photomicrographs and microscopic anatomy.