Jiamin Song, Wenxin Li, Guoyue Yuan, Dong Wang, Li Zhao
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引用次数: 0
摘要
目的：探讨甲状腺功能正常的2型糖尿病（T2DM）患者甲状腺功能、甲状腺激素指标敏感性及骨密度（BMD）之间的关系。方法：选取536例甲状腺功能正常的T2DM患者。测量受试者的人体测量参数、生化指标和临床特征。通过双能x线检测骨密度，并根据结果对其进行分类。结果：与骨密度正常组比较，低骨密度组FT3水平明显降低（P < 0.05）。根据FT3将患者依次分配到三分位数。与第1组相比，第2组患者的BMD值更高。Spearman相关分析显示FT3水平与BMD呈正相关。经多元线性回归调整后，FT3水平仍与骨密度降低显著相关。校正潜在混杂变量后，多重logistic回归分析发现FT3与BMD之间存在显著的独立相关性（OR= 0.187, P < 0.05）。甲状腺激素指标与骨密度无显著相关性。结论：T2DM甲状腺功能正常患者的FT3水平与BMD独立相关。高正常值的FT3可能是BMD的保护因素。
A high FT3 level might protect bone mineral density among euthyroid type 2 diabetes mellitus patients.
Objectives: This research was to investigate the relationship among thyroid function, sensitivity to thyroid hormone indices, and bone mineral density (BMD) in euthyroid individuals with type 2 diabetes mellitus (T2DM).
Methods: A total of 536 euthyroid patients with T2DM were included. The subjects were measured for anthropometric parameters, biochemical indicators, and clinical characteristics. Their bone density was tested by dual-energy X-ray, and then they were classified according to their outcomes.
Results: In comparison to the normal BMD group, the FT3 level was notably reduced in the low BMD groups (P < 0.05). The patients were sequentially assigned to tri-sectional quantiles according to FT3. Compared with tertile 1, patients in tertile 2 had a higher value of BMD. Spearman correlation analysis showed that the FT3 level was positively associated with BMD. After adjustment in multiple linear regression, FT3 level remained significantly related to decreased BMD. A significant independent association between FT3 and BMD was found by multiple logistic regression analysis after adjusting for potential confounding variables (OR = 0.187, P < 0.05). No significant relation was found between thyroid hormone indices and BMD.
Conclusion: FT3 level was independently associated with BMD in euthyroid patients with T2DM. High-normal FT3 may be a protective factor for BMD.
期刊介绍：
Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.
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