tmd患者的髁突骨吸收。

Craniofacial growth series Pub Date : 2009-03-01
Lucia H Cevidanes, David G Walker, Martin Styner, Pei Feng Lim
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引用次数: 0

摘要

本研究的目的是利用锥形束CT (CBCT)图像构建的三维表面模型,确定骨关节炎颞下颌关节(TMJ)与非骨关节炎颞下颌关节(TMJ)髁突形态的差异。采用三维形状对应法对20例RDC/TMD III组患者(关节痛、关节炎、关节病)与40例无症状患者的髁突形态差异进行定位和量化。根据CBCT图像构建每个受试者的左右髁三维模型,并使用公开的spham - pdm软件进行形状分析。左右髁采用刚性Procrustes对齐归一化到每组整体平均髁表面。使用Hotelling T2分析和置换检验得出的p值比较各组之间的平均差异,并校正了错误发现率。各组平均表面之间的差异用颜色编码的幅度和差异向量可视化。TMD组与无症状组髁突形态差异有统计学意义(p = 0.05,右髁平均表面距离差异1.9 mm,左髁平均表面距离差异2.3 mm)。与无症状患者的平均形态相比,TMD患者的平均髁突形态显示外侧极前表面吸收和关节表面变平。TMD患者的髁突形态和尺寸平均与无症状者不同。本横断面研究的初步结果将引导未来的研究,以阐明骨关节炎在TMD中的变化及其在TMD病理生理中的作用。NIDCR DE017727支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CONDYLAR RESORPTION IN PATIENTS WITH TMD.

The objective of this study is to determine the nature of the difference between condyle morphology of osteoarthritic temporomandibular joint (TMJ) and non-osteoarthritic TMJ, using 3D surface models constructed from cone-beam CT (CBCT) images. Three-dimensional Shape Correspondence was used to localize and quantify condylar morphological differences of 20 patients with RDC/TMD group III (arthralgia, arthritis, arthrosis) compared to 40 asymptomatic subjects. Three-dimensional models of right and left condyles for each subject were constructed from CBCT images and shape analysis performed using the publicly available SPHARM-PDM software. The right and left condyles were normalized using rigid Procrustes alignment to an overall mean condylar surface per group. The mean differences between groups were compared using the Hotelling T2 analysis with permutation-test derived p-values, corrected for False Discovery Rate. The differences between the group mean surfaces were visualized with color-coded magnitude and difference vectors. The condylar morphology of the TMD group was statistically significantly different from the asymptomatic group (p = 0.05, average surface distance differences of 1.9 mm for the right condyles and 2.3 mm for the left condyles). The average condylar morphology in the TMD patients showed resorption of the anterior surface of the lateral pole and flattening of the articular surface compared to the mean morphology in asymptomatic subjects. The condylar morphology and condylar dimensions of the TMD patients were different, on average, from those of the asymptomatic subjects. The preliminary findings in this cross-sectional study will lead to future investigations to elucidate osteoarthritic changes in TMD and their role in the pathophysiology of TMD. Supported by NIDCR DE017727.

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