非转移性非小细胞肺癌切除患者的流行病学、患者管理和生存结果:一项全国性的现实世界研究。

IF 3.4 2区 医学 Q2 ONCOLOGY
Stéphane Renaud, Paul Casabianca, Pauline Diez-Andreu, Mélanie Chartier, Anne-Françoise Gaudin, Françoise Bugnard, Stève Bénard, François-Emery Cotté, Christos Chouaid
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引用次数: 0

摘要

手术是符合条件的局部或IIIA期局部晚期非小细胞肺癌(NSCLC)患者的标准治疗方法,目前的指南推荐最保守的手术。本研究的目的是为非转移性非小细胞肺癌切除术患者的流行病学、治疗和生存结果提供新的现实数据。材料和方法:这是一项描述性、非介入性、全国性、回顾性索赔研究,使用来自法国国家住院数据库(PMSI)的数据,描述了2015年至2019年期间接受首次肺切除术(LR)的非转移性非小细胞肺癌患者的管理。对2015年行LR的患者进行随访,直至最后一次登记的医院护理或院内死亡。评估5年无病生存期(DFS[即从LR到首次复发或死亡的时间])和总生存期(OS)。结果:2015年至2019年期间,非转移性NSCLC和首次LR患者的比例平均每年增长4.5%(2015年为8,688人,2019年为10,330人)。肺叶切除术(79.8%对84.9%)和电视胸腔镜手术(29.6%对46.4%)更为频繁。肺叶下切除术后的5年DFS为33.7% [95%CI 29.8-37.6%],肺叶切除术后的5年DFS为52.3%[51.0-53.5%],胆叶切除术后的5年DFS为42.3%[36.9-47.5%],全肺切除术后的5年DFS为33.6%[30.0-37.2%]。LR的5年OS分别为58.4%[54.1-62.4]、70.2%[69.0-71.3]、59.3%[53.7-64.4]和46.3%[42.3-50.2]。结论:本研究强调了保守和微创手术在非小细胞肺癌切除术中的增加趋势。LR类型可作为疾病扩展的间接标志,在广泛手术的情况下生存结果较差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology, patient management, and survival outcomes in resected patients with non-metastatic non-small cell lung cancer: a nationwide real-world study.

Introduction: Surgery is the standard of care for eligible patients with localized or stage IIIA locally advanced non-small cell lung cancer (NSCLC) current guidelines recommend the most conservative surgeries possible. The aim of this study was to bring new real-world data on resected NSCLC epidemiology, management, and survival outcomes in patients with resected non-metastatic NSCLC.

Materials and methods: This is a descriptive, non-interventional, national, retrospective claims study using data from the French National Hospitalization Database (PMSI) describing the management of patients with non-metastatic NSCLC who underwent a first lung resection (LR) between 2015 and 2019. Patients with LR performed in 2015 were followed from LR until the last registered hospital care or in-hospital death. Five-year disease-free survival (DFS [i.e., time from LR to first recurrence or death]) and overall survival (OS) were assessed.

Results: The rate of patients with non-metastatic NSCLC and a first LR between 2015 and 2019 increased by an average of 4.5% per year (8,688 in 2015 vs. 10,330 in 2019). Lobectomy (79.8% vs. 84.9%) and video-assisted thoracoscopic surgery (29.6% vs. 46.4%) became more frequent. Five-year DFS was 33.7% [95%CI 29.8-37.6%] following infralobar resection, 52.3% [51.0-53.5%] after lobectomy, 42.3% [36.9-47.5%] after bilobectomy, and 33.6% [30.0-37.2%] after pneumonectomy. Respective five-year OS from LR were 58.4% [54.1-62.4], 70.2% [69.0-71.3], 59.3% [53.7-64.4], and 46.3% [42.3-50.2].

Conclusions: This study highlights the increasing trend toward conservative and less invasive surgeries in resected NSCLC. Type of LR can be used as an indirect marker of disease expansion, with poorer survival outcomes in case of extensive surgeries.

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来源期刊
BMC Cancer
BMC Cancer 医学-肿瘤学
CiteScore
6.00
自引率
2.60%
发文量
1204
审稿时长
6.8 months
期刊介绍: BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.
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