c反应蛋白与淋巴细胞比值与胆结石的关系:一项横断面研究。

IF 2.5 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Xiaoyang Sun, Jie Lin, Zhenao Wang, Chenfang Zhang, Kai Zhao, Xuewen Zhang, Jiyao Sheng
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引用次数: 0

摘要

背景:炎症在胆结石的发展中起着关键作用,c反应蛋白与淋巴细胞比率(CLR)已被引入作为评估炎症过程的有前途的生物标志物。尽管如此,其与胆结石患病率的相关性仍不明确。本研究旨在评估CLR水平与胆结石患病率之间的潜在联系。方法:本研究利用国家健康与营养检查调查的数据,时间为2017年3月至2020年和2021年至2023年。采用多因素logistic回归分析CLR与胆结石患病率之间的关系。此外,进行平滑曲线拟合,亚组分析和相互作用检验以提供综合评价。我们还采用受试者工作特征(ROC)曲线来确定该指标对胆结石的预测能力。结果:在这项研究的13386名参与者中,1444人被诊断患有胆结石。在一个完全调整的模型中,观察到CLR与胆结石患病率之间存在较小但具有统计学意义的正相关(优势比[OR] = 1.07, 95% CI: 1.01-1.12)。与CLR最低分位(T1)的个体相比,中等分位(T2)的个体胆结石患病率升高无统计学意义(OR = 1.10, 95% CI: 0.94-1.29),而最高分位(T3)的个体胆结石患病率升高有统计学意义(OR = 1.20, 95% CI: 1.03-1.41)。平滑曲线拟合进一步证实了这种正相关关系。bonferroni校正亚组分析显示,在“已婚/同居”亚组中,CLR与胆结石有统计学意义(P < 0.0038)。结论:高CLR与高胆结石患病率相关。然而,需要更多的大规模前瞻性研究来进一步研究CLR在胆结石患病率中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between C-reactive protein to lymphocyte ratio and gallstones: a cross-sectional study.

Background: Inflammation plays a key role in the development of gallstones, and the C-reactive protein to lymphocyte ratio (CLR) has been introduced as a promising biomarker for evaluating inflammatory processes. Nonetheless, its correlation with gallstone prevalence remains ambiguous. This study aims to evaluate the potential link between CLR levels and gallstone prevalence.

Methods: This study utilized data from the National Health and Nutrition Examination Survey, covering the periods from March 2017 to 2020 and 2021 to 2023. Multivariate logistic regression was employed to examine the association between CLR and gallstone prevalence. Furthermore, smoothed curve fitting, subgroup analysis, and interaction testing were performed to provide a comprehensive evaluation. We also employed receiver operating characteristic (ROC) curves to determine the predictive ability of the index for gallstones.

Results: Among the 13,386 participants included in this study, 1,444 were diagnosed with gallstones. In a fully adjusted model, a small but statistically significant positive association between CLR and the prevalence of gallstones was observed (odds ratio [OR] = 1.07, 95% CI: 1.01-1.12). Compared to individuals in the lowest tertile of CLR (T1), those in the middle tertile (T2) showed a non-significant increase in gallstone prevalence (OR = 1.10, 95% CI: 0.94-1.29), while the highest tertile (T3) exhibited a statistically significant elevation (OR = 1.20, 95% CI: 1.03-1.41). Smoothed curve fitting further confirmed this positive relationship. Bonferroni-corrected subgroup analysis demonstrated a statistically significant association between CLR and gallstones in the "Married/Living with Partner" subgroup (P < 0.0015), while no significant associations were observed in the other subgroups. Additionally, Bonferroni-corrected interaction tests indicated no significant interactions between CLR and gallstones across all subgroups (P for interaction > 0.0038).

Conclusion: Higher CLR was associated with higher gallstone prevalence. However, additional large-scale prospective studies are required to further investigate the role of CLR in the prevalence of gallstones.

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来源期刊
BMC Gastroenterology
BMC Gastroenterology 医学-胃肠肝病学
CiteScore
4.20
自引率
0.00%
发文量
465
审稿时长
6 months
期刊介绍: BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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