亚氨基糖c -香豆素苷直接合成顺式双环γ-内酰胺衍生物

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-30 DOI:10.1021/acs.orglett.5c01201

Likai Zhou, Lijing Feng, Jilai Wu, Chao Wei, Hua Chen

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引用次数: 0

摘要

通过曼尼希反应和跨环反应机制，建立了一种简单有效的合成方法，将亚糖c -香豆素基糖苷4a转化为顺式双环γ-内酰胺衍生物8a。这种方法的适应性已经通过各种取代香豆素、甲酰糖和胺被证明。拉伸反应证明了双环骨架的可塑性。此外，该反应还具有操作简单、收率高、原子经济性高等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct Synthesis of cis-Bicyclic γ-Lactam Derivatives from Iminosugar C-Coumarinyl Glycosides

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Direct Synthesis of cis-Bicyclic γ-Lactam Derivatives from Iminosugar C-Coumarinyl Glycosides

A simple and effective synthesis method has been developed through Mannich and transannular reaction mechanisms to convert iminosugar C-coumarinyl glycosides 4a into cis-bicyclic γ-lactam derivatives 8a. The adaptability of this method has been demonstrated through various substituted coumarins, tosylated sugars, and amines. The extension reaction proved the plasticity of the bicyclic skeleton. In addition, this reaction has the characteristics of simple operation, a high yield, and high atomic economy.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.