肺移植受者1年体育训练计划：一项随机对照试验

IF 7.7 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2025-05-30 DOI:10.1136/thorax-2024-222896

Sofie Breuls, Astrid Blondeel, Marieke Wuyts, Geert M Verleden, Robin Vos, Wim Janssens, Thierry Troosters, Heleen Demeyer

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引用次数: 0

摘要

大多数肺移植（LTX）受者不符合身体活动（PA）指南。需要采取干预措施，因为长期不活动与发病率和死亡率有关。我们调查了远程教学计划对LTX受者客观测量PA的影响。方法将不活动的患者（<7500步/天，n=90）随机分为1年PA远程教学计划的轻度或强化版本。灯光干预包括一个计数器和一个最小版本的智能手机应用程序。随机分配到强化干预组的患者讨论了PA障碍和目标，接收了一个计步器、一个为患者量身定制的智能手机应用程序和支持性指导电话。在基线、3个月（主要终点）和1年后分别测量PA（主要终点，通过加速度计评估）、身体功能、生活质量和症状。使用混合模型分析来调查干预与轻度干预的有效性。结果3个月和1年后的组间变化差异为平均（CI）每天750(- 96至1596)（p=0.08）和680（- 244至1605）步（p=0.15），总运动时间（步行、爬楼梯和骑自行车）10（- 0.5至20）和10（- 1至22）分钟（p=0.07），久坐时间- 3(- 6至0)（p=0.07）和- 6(- 10至2)(p=0.002)，均有利于干预组。其他结果在两组之间没有差异。结论与轻度远程教学相比，强化远程教学可改善LTX受者的PA。试验注册号[NCT04122768][1]。如有合理要求，可提供资料。根据比利时法律，由于患者保密，数据不能公开共享。新的分析可根据作者或鲁汶大学伦理委员会的合理要求提供（ec@uzleuven.be）。[1]: /查找/ external-ref ? link_type = CLINTRIALGOV&access_num = NCT04122768&atom = % 2 fthoraxjnl % 2恐惧% 2 f2025 % 2 f05 % 2 f29 % 2 fthorax - 2024 - 222896. -原子

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1-year physical activity coaching programme in lung transplant recipients: an RCT

Introduction Most lung transplant (LTX) recipients do not meet physical activity (PA) guidelines. Interventions are needed as long-term inactivity is related to morbidity and mortality. We investigated the effect of a telecoaching programme on objectively measured PA in LTX recipients. Methods Inactive patients (<7500 steps/day, n=90) were randomised into a light or intensive version of a 1-year PA telecoaching programme. The light intervention consisted of a step counter and a minimal version of the smartphone application. Patients randomised to the intensive intervention discussed PA barriers and goals, received a step counter, a patient-tailored smartphone application and supportive coaching calls. PA (primary outcome, assessed by an accelerometer), physical function, quality of life and symptoms were measured at baseline, after 3 months (primary endpoint) and 1 year. Mixed model analyses were used to investigate the effectiveness of the intervention compared with the light intervention. Results Between-group difference in change after 3 months and 1 year was observed as mean (CI) 750 (−96 to 1596) (p=0.08) and 680 (−244 to 1605) steps per day (p=0.15), 10 (−0.5 to 20) and 10 (−1 to 22) min of total moving time (walking, taking stairs and cycling) (both p=0.07) and −3 (−6 to 0) (p=0.07) and −6 (−10 to −2) (p=0.002) of sedentary time, all in favour of the intervention group. Other outcomes did not differ between groups. Conclusion PA tends to improve in LTX recipients by following an intensive telecoaching programme compared with a light programme. Trial registration number [NCT04122768][1]. Data are available upon reasonable request. Data cannot be shared publicly because of patient confidentiality according to the Belgian law. New analyses are available on reasonable request from the author or UZ Leuven ethical committee’ (ec@uzleuven.be). [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT04122768&atom=%2Fthoraxjnl%2Fearly%2F2025%2F05%2F29%2Fthorax-2024-222896.atom

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.