Julian Freier, Leon Brückner, Bastian Löhrl, Maya Shariff, Luitpold Distel, Christoph Bert, Peter Hommelhoff
{"title":"用EBT3 GafChromic薄膜对12 ~ 45kev范围内的低能电子进行剂量测定。","authors":"Julian Freier, Leon Brückner, Bastian Löhrl, Maya Shariff, Luitpold Distel, Christoph Bert, Peter Hommelhoff","doi":"10.1088/1361-6560/adde28","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective.</i>Low energy electrons (LEEs) in the range of tens of keV combine high relative biological effectiveness with low penetration depth in tissue, making them an interesting tool for radiobiological studies. To harness these advantages, a reliable and comprehensible dosimetry method is essential.<i>Approach.</i>Unlaminated EBT3 GafChromic films were evaluated as potential LEE dosimeters, given the limitations of other dosimetry tools for LEE applications. The depth dose profile of the LEE in the film was simulated and then combined with the experimentally determined response of the film to a calibrated radiation source. Using this, the total response of the film for a given average dose was calculated.<i>Main results.</i>A calibration curve for unlaminated EBT3 GafChromic films for LEE in the energy range of 12-45 keV has been successfully developed for a range of average doses from 0 Gy to 16 Gy.<i>Significance.</i>The developed calibration curve enables direct, quantitative comparison of biological experiments using LEE with other types of radiation such as x-rays, facilitating the adoption of LEE in radiobiological research.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dosimetry for low energy electrons in the range of 12-45 keV with EBT3 GafChromic films.\",\"authors\":\"Julian Freier, Leon Brückner, Bastian Löhrl, Maya Shariff, Luitpold Distel, Christoph Bert, Peter Hommelhoff\",\"doi\":\"10.1088/1361-6560/adde28\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Objective.</i>Low energy electrons (LEEs) in the range of tens of keV combine high relative biological effectiveness with low penetration depth in tissue, making them an interesting tool for radiobiological studies. To harness these advantages, a reliable and comprehensible dosimetry method is essential.<i>Approach.</i>Unlaminated EBT3 GafChromic films were evaluated as potential LEE dosimeters, given the limitations of other dosimetry tools for LEE applications. The depth dose profile of the LEE in the film was simulated and then combined with the experimentally determined response of the film to a calibrated radiation source. Using this, the total response of the film for a given average dose was calculated.<i>Main results.</i>A calibration curve for unlaminated EBT3 GafChromic films for LEE in the energy range of 12-45 keV has been successfully developed for a range of average doses from 0 Gy to 16 Gy.<i>Significance.</i>The developed calibration curve enables direct, quantitative comparison of biological experiments using LEE with other types of radiation such as x-rays, facilitating the adoption of LEE in radiobiological research.</p>\",\"PeriodicalId\":20185,\"journal\":{\"name\":\"Physics in medicine and biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics in medicine and biology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1361-6560/adde28\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/adde28","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Dosimetry for low energy electrons in the range of 12-45 keV with EBT3 GafChromic films.
Objective.Low energy electrons (LEEs) in the range of tens of keV combine high relative biological effectiveness with low penetration depth in tissue, making them an interesting tool for radiobiological studies. To harness these advantages, a reliable and comprehensible dosimetry method is essential.Approach.Unlaminated EBT3 GafChromic films were evaluated as potential LEE dosimeters, given the limitations of other dosimetry tools for LEE applications. The depth dose profile of the LEE in the film was simulated and then combined with the experimentally determined response of the film to a calibrated radiation source. Using this, the total response of the film for a given average dose was calculated.Main results.A calibration curve for unlaminated EBT3 GafChromic films for LEE in the energy range of 12-45 keV has been successfully developed for a range of average doses from 0 Gy to 16 Gy.Significance.The developed calibration curve enables direct, quantitative comparison of biological experiments using LEE with other types of radiation such as x-rays, facilitating the adoption of LEE in radiobiological research.
期刊介绍:
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry