Dongdong Liu, Shaopeng Huang, Yue Yuan, Jinfeng Liu
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Identification of NLRP3 Inflammasome-associated Biomarkers by Integrated Bioinformatics Analysis in Neuropathic Pain.
Neuropathic pain (NP) is a chronic disease due to nerve injury, viral infections, etc. Inflammatory factors are a key part of its pathological mechanism, and NLRP3 has been widely studied in other diseases; however, its study in NP is still scarce. We analyzed genes differentially expressed in NP and normal samples using public databases. Six key markers were screened by WGCNA and a machine learning approach. The research value of key markers in NP was further verified by correlation analysis, expression analysis and validation, regulatory network construction, and molecular docking. Our results identified six reliable key markers: Lyz2, Fcgr4, Gm2a, Sumf1, Zbtb7a, and Treml2. After correlation analysis and molecular functional similarity analysis, it was concluded that Lyz2 might be a key marker of NLRP3 with greater potential in NP. Our study may find new targets for NP.
期刊介绍:
Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.