神经性疼痛中NLRP3炎性小体相关生物标志物的综合生物信息学分析

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Molecular Neurobiology Pub Date : 2025-10-01 Epub Date: 2025-05-29 DOI:10.1007/s12035-025-04999-y
Dongdong Liu, Shaopeng Huang, Yue Yuan, Jinfeng Liu
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引用次数: 0

摘要

神经性疼痛是一种由神经损伤、病毒感染等引起的慢性疾病。炎症因子是其病理机制的关键部分,NLRP3在其他疾病中得到了广泛的研究;然而,其在NP领域的研究还比较少。我们利用公共数据库分析了NP和正常样本中差异表达的基因。通过WGCNA和机器学习方法筛选了6个关键标记。通过相关分析、表达分析与验证、调控网络构建、分子对接等进一步验证了NP中关键标记的研究价值。我们的结果确定了六个可靠的关键标记:Lyz2, Fcgr4, Gm2a, Sumf1, Zbtb7a和Treml2。通过相关分析和分子功能相似性分析,认为Lyz2可能是NLRP3的关键标记物,在NP中具有较大的潜力。我们的研究可能会发现NP的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of NLRP3 Inflammasome-associated Biomarkers by Integrated Bioinformatics Analysis in Neuropathic Pain.

Neuropathic pain (NP) is a chronic disease due to nerve injury, viral infections, etc. Inflammatory factors are a key part of its pathological mechanism, and NLRP3 has been widely studied in other diseases; however, its study in NP is still scarce. We analyzed genes differentially expressed in NP and normal samples using public databases. Six key markers were screened by WGCNA and a machine learning approach. The research value of key markers in NP was further verified by correlation analysis, expression analysis and validation, regulatory network construction, and molecular docking. Our results identified six reliable key markers: Lyz2, Fcgr4, Gm2a, Sumf1, Zbtb7a, and Treml2. After correlation analysis and molecular functional similarity analysis, it was concluded that Lyz2 might be a key marker of NLRP3 with greater potential in NP. Our study may find new targets for NP.

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来源期刊
Molecular Neurobiology
Molecular Neurobiology 医学-神经科学
CiteScore
9.00
自引率
2.00%
发文量
480
审稿时长
1 months
期刊介绍: Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.
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