{"title":"准直口径质子束线扫描在立体定向放疗中的剂量学评价及临床应用。","authors":"Chen-Yu Chou, Hsiao-Chieh Huang, Shen-Hao Lee, Shih-Ming Hsu","doi":"10.1002/acm2.70128","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Stereotactic radiotherapy (SRT) is a highly effective treatment with precision for small, localized lesions. Proton therapy, characterized by the Bragg peak, offers superior dose conformity compared to photon-based approaches. However, challenges remain in minimizing lateral penumbra and optimizing dose delivery, particularly for small targets. This study presents the first clinical application of collimated apertures integrated with the proton line scanning technique for proton stereotactic radiotherapy (PSRT). The aim was to evaluate the dosimetric advantages and clinical feasibility of this innovative approach.</p><p><strong>Methods: </strong>Over a 1-year period, 30 patients with small lesions, including choroid melanoma and arteriovenous malformations, were treated using proton line scanning. Two planning strategies were evaluated: uncollimated proton line scanning (UPLS) and collimated proton line scanning (CPLS), incorporating patient-specific apertures. Dosimetric comparisons were conducted using the Homogeneity Index (HI), Paddick Conformity Index (CI<sub>Paddick</sub>), Gradient Index (GI), and R50%. Treatment accuracy was validated using absolute dose measurements and Gamma Passing Rate (GPR) analysis under the criteria of 3%/3 and 2%/2 mm.</p><p><strong>Results: </strong>Plans incorporating customized collimated apertures showed significant improvements in dose conformity, with higher CI<sub>Paddick</sub> values (p < 0.001), and exhibited steeper dose fall-off, as reflected in lower GI and R50% values (p < 0.001). A trend toward more homogeneous dose distributions was also observed (p < 0.001). GPR analysis confirmed high treatment accuracy, with an average value of 99.00 ± 1.83% (3%/3 mm) and 91.06 ± 4.91% (2%/2 mm).</p><p><strong>Conclusions: </strong>Integrating customized collimated apertures with proton beam line scanning is clinically feasible, improving precision, dose conformity, and healthy tissue sparing in PSRT. These findings support adopting this novel approach to advance precision proton therapy for small lesions.</p>","PeriodicalId":14989,"journal":{"name":"Journal of Applied Clinical Medical Physics","volume":" ","pages":"e70128"},"PeriodicalIF":2.0000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dosimetric evaluation and clinical application of collimated apertures with proton beam line scanning in stereotactic radiotherapy.\",\"authors\":\"Chen-Yu Chou, Hsiao-Chieh Huang, Shen-Hao Lee, Shih-Ming Hsu\",\"doi\":\"10.1002/acm2.70128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Stereotactic radiotherapy (SRT) is a highly effective treatment with precision for small, localized lesions. Proton therapy, characterized by the Bragg peak, offers superior dose conformity compared to photon-based approaches. However, challenges remain in minimizing lateral penumbra and optimizing dose delivery, particularly for small targets. This study presents the first clinical application of collimated apertures integrated with the proton line scanning technique for proton stereotactic radiotherapy (PSRT). The aim was to evaluate the dosimetric advantages and clinical feasibility of this innovative approach.</p><p><strong>Methods: </strong>Over a 1-year period, 30 patients with small lesions, including choroid melanoma and arteriovenous malformations, were treated using proton line scanning. Two planning strategies were evaluated: uncollimated proton line scanning (UPLS) and collimated proton line scanning (CPLS), incorporating patient-specific apertures. Dosimetric comparisons were conducted using the Homogeneity Index (HI), Paddick Conformity Index (CI<sub>Paddick</sub>), Gradient Index (GI), and R50%. Treatment accuracy was validated using absolute dose measurements and Gamma Passing Rate (GPR) analysis under the criteria of 3%/3 and 2%/2 mm.</p><p><strong>Results: </strong>Plans incorporating customized collimated apertures showed significant improvements in dose conformity, with higher CI<sub>Paddick</sub> values (p < 0.001), and exhibited steeper dose fall-off, as reflected in lower GI and R50% values (p < 0.001). A trend toward more homogeneous dose distributions was also observed (p < 0.001). GPR analysis confirmed high treatment accuracy, with an average value of 99.00 ± 1.83% (3%/3 mm) and 91.06 ± 4.91% (2%/2 mm).</p><p><strong>Conclusions: </strong>Integrating customized collimated apertures with proton beam line scanning is clinically feasible, improving precision, dose conformity, and healthy tissue sparing in PSRT. These findings support adopting this novel approach to advance precision proton therapy for small lesions.</p>\",\"PeriodicalId\":14989,\"journal\":{\"name\":\"Journal of Applied Clinical Medical Physics\",\"volume\":\" \",\"pages\":\"e70128\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Clinical Medical Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/acm2.70128\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Clinical Medical Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/acm2.70128","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Dosimetric evaluation and clinical application of collimated apertures with proton beam line scanning in stereotactic radiotherapy.
Purpose: Stereotactic radiotherapy (SRT) is a highly effective treatment with precision for small, localized lesions. Proton therapy, characterized by the Bragg peak, offers superior dose conformity compared to photon-based approaches. However, challenges remain in minimizing lateral penumbra and optimizing dose delivery, particularly for small targets. This study presents the first clinical application of collimated apertures integrated with the proton line scanning technique for proton stereotactic radiotherapy (PSRT). The aim was to evaluate the dosimetric advantages and clinical feasibility of this innovative approach.
Methods: Over a 1-year period, 30 patients with small lesions, including choroid melanoma and arteriovenous malformations, were treated using proton line scanning. Two planning strategies were evaluated: uncollimated proton line scanning (UPLS) and collimated proton line scanning (CPLS), incorporating patient-specific apertures. Dosimetric comparisons were conducted using the Homogeneity Index (HI), Paddick Conformity Index (CIPaddick), Gradient Index (GI), and R50%. Treatment accuracy was validated using absolute dose measurements and Gamma Passing Rate (GPR) analysis under the criteria of 3%/3 and 2%/2 mm.
Results: Plans incorporating customized collimated apertures showed significant improvements in dose conformity, with higher CIPaddick values (p < 0.001), and exhibited steeper dose fall-off, as reflected in lower GI and R50% values (p < 0.001). A trend toward more homogeneous dose distributions was also observed (p < 0.001). GPR analysis confirmed high treatment accuracy, with an average value of 99.00 ± 1.83% (3%/3 mm) and 91.06 ± 4.91% (2%/2 mm).
Conclusions: Integrating customized collimated apertures with proton beam line scanning is clinically feasible, improving precision, dose conformity, and healthy tissue sparing in PSRT. These findings support adopting this novel approach to advance precision proton therapy for small lesions.
期刊介绍:
Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission.
JACMP will publish:
-Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500.
-Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed.
-Technical Notes: These should be no longer than 3000 words, including key references.
-Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents.
-Book Reviews: The editorial office solicits Book Reviews.
-Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics.
-Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic