准直口径质子束线扫描在立体定向放疗中的剂量学评价及临床应用。

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Chen-Yu Chou, Hsiao-Chieh Huang, Shen-Hao Lee, Shih-Ming Hsu
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引用次数: 0

摘要

目的:立体定向放射治疗(SRT)是一种非常有效的治疗方法,精度小,局部病变。质子治疗以Bragg峰为特征,与基于光子的方法相比,提供了更好的剂量一致性。然而,在最大限度地减少侧影和优化剂量递送方面仍然存在挑战,特别是对于小靶点。本研究首次将准直口径结合质子线扫描技术应用于质子立体定向放射治疗(PSRT)。目的是评估这种创新方法的剂量学优势和临床可行性。方法:对30例脉络膜黑色素瘤、动静脉畸形等小病变患者进行质子线扫描治疗。评估了两种计划策略:未准直质子线扫描(UPLS)和准直质子线扫描(CPLS),结合患者特定的孔径。采用均匀性指数(HI)、帕迪克一致性指数(CIPaddick)、梯度指数(GI)和R50%进行剂量学比较。在3%/3和2%/2 mm的标准下,通过绝对剂量测量和伽马通过率(GPR)分析验证了治疗的准确性。结果:结合定制准直孔的方案在剂量一致性方面有显著改善,CIPaddick值更高(p)。结论:将定制准直孔与质子束线扫描结合在一起,在临床上是可行的,可以提高PSRT的精度、剂量一致性和健康组织保护。这些发现支持采用这种新方法来推进小病变的精确质子治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dosimetric evaluation and clinical application of collimated apertures with proton beam line scanning in stereotactic radiotherapy.

Purpose: Stereotactic radiotherapy (SRT) is a highly effective treatment with precision for small, localized lesions. Proton therapy, characterized by the Bragg peak, offers superior dose conformity compared to photon-based approaches. However, challenges remain in minimizing lateral penumbra and optimizing dose delivery, particularly for small targets. This study presents the first clinical application of collimated apertures integrated with the proton line scanning technique for proton stereotactic radiotherapy (PSRT). The aim was to evaluate the dosimetric advantages and clinical feasibility of this innovative approach.

Methods: Over a 1-year period, 30 patients with small lesions, including choroid melanoma and arteriovenous malformations, were treated using proton line scanning. Two planning strategies were evaluated: uncollimated proton line scanning (UPLS) and collimated proton line scanning (CPLS), incorporating patient-specific apertures. Dosimetric comparisons were conducted using the Homogeneity Index (HI), Paddick Conformity Index (CIPaddick), Gradient Index (GI), and R50%. Treatment accuracy was validated using absolute dose measurements and Gamma Passing Rate (GPR) analysis under the criteria of 3%/3 and 2%/2 mm.

Results: Plans incorporating customized collimated apertures showed significant improvements in dose conformity, with higher CIPaddick values (p < 0.001), and exhibited steeper dose fall-off, as reflected in lower GI and R50% values (p < 0.001). A trend toward more homogeneous dose distributions was also observed (p < 0.001). GPR analysis confirmed high treatment accuracy, with an average value of 99.00 ± 1.83% (3%/3 mm) and 91.06 ± 4.91% (2%/2 mm).

Conclusions: Integrating customized collimated apertures with proton beam line scanning is clinically feasible, improving precision, dose conformity, and healthy tissue sparing in PSRT. These findings support adopting this novel approach to advance precision proton therapy for small lesions.

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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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