韩国脂肪变性肝病亚型及其与结直肠癌风险的关系：一项基于全国人群的研究

IF 3.6 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Digestion Pub Date : 2025-05-28 DOI:10.1159/000546376

Sang Yi Moon, Minkook Son, Jong Yoon Lee, Yeo Wool Kang, Myeongseok Koh

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引用次数: 0

摘要

背景：最近的德尔菲共识提出了一种新的脂肪变性肝病（SLD）分类系统，取代了以前的术语非酒精性脂肪性肝病（NAFLD）。本研究旨在探讨SLD亚型与结直肠癌（CRC）发生风险之间的关系。方法：我们使用韩国国民健康保险服务数据库确定2009年和2010年接受健康筛查的参与者，并回顾性分析其数据至2019年。参与者被分为四类：无SLD、代谢功能障碍相关脂肪变性肝病（MASLD）、酒精摄入增加的MASLD （MetALD）和酒精相关肝病（ALD）。肝脂肪变性定义为脂肪肝指数≥30。根据SLD分类，主要结局是新诊断的CRC的发生。结果：该分析包括242,275名参与者。MASLD校正后的CRC发病率风险比为1.17(95%可信区间[CI]: 1.10-1.25)， MetALD校正后的风险比为1.45 (95% CI: 1.28-1.65)， ALD校正后的风险比为1.78 (95% CI: 1.48-2.14)，没有SLD作为参照组。所有结果均有统计学意义（p < 0.001）。结论：韩国患有MASLD、MetALD或ALD的个体发生CRC的风险增加。

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Steatotic Liver Disease Subtypes and Their Association with Colorectal Cancer Risk in Korea: A Nationwide Population-Based Study.

Introduction: A recent Delphi consensus proposed a new classification system for steatotic liver disease (SLD), replacing the previous terminology, non-alcoholic fatty liver disease. This study aimed to examine the association between SLD subtypes and the risk of developing colorectal cancer (CRC).

Methods: We used the Korean National Health Insurance Service database to identify participants who underwent health screenings in 2009 and 2010 and retrospectively analyzed their data through to 2019. The participants were grouped into four categories: no SLD, metabolic dysfunction-associated SLD (MASLD), MASLD with increased alcohol intake (MetALD), and alcohol-related liver disease (ALD). Hepatic steatosis was defined as a fatty liver index ≥30. The primary outcome was the occurrence of newly diagnosed CRC according to the SLD classification.

Results: This analysis included 242,275 participants. The adjusted hazard ratios for CRC incidence were 1.17 (95% confidence interval [CI]: 1.10-1.25) for MASLD, 1.45 (95% CI: 1.28-1.65) for MetALD, and 1.78 (95% CI: 1.48-2.14) for ALD, with no SLD as the reference group. All results were statistically significant (p < 0.001).

Conclusion: Individuals in Korea with MASLD, MetALD, or ALD are at an increased risk of developing CRC.

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来源期刊

Digestion 医学-胃肠肝病学

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.