Kelsey R. Sewell, Audrey M. Collins, Lauren E. Oberlin, Miranda G. Chappel-Farley, Haiqing Huang, George Grove, John M. Jakicic, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Anna L. Marsland, Chaeryon Kang, Lu Wan, Kristine A. Wilckens, Kirk I. Erickson
{"title":"体育活动可以减轻老年人睡眠相关的认知缺陷：来自IGNITE研究的发现","authors":"Kelsey R. Sewell, Audrey M. Collins, Lauren E. Oberlin, Miranda G. Chappel-Farley, Haiqing Huang, George Grove, John M. Jakicic, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Anna L. Marsland, Chaeryon Kang, Lu Wan, Kristine A. Wilckens, Kirk I. Erickson","doi":"10.1002/trc2.70110","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Poor sleep is commonly associated with poorer cognition in older adults. Unfortunately, effective sleep improvement therapies for older adults are limited in their accessibility and have shown only subtle effects on cognition. Physical activity, however, is associated with better cognition in older adults and may compensate for cognitive deficits related to poor sleep. This study examined whether greater engagement in physical activity moderates the association between sleep and cognitive function in older adults.</p>\n </section>\n \n <section>\n \n <h3> METHODOLOGY</h3>\n \n <p>We utilized baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study. Cognitively unimpaired older adults (<i>n</i> = 589, mean age ± SD: 69.8 ± 3.7, 70% female) underwent a comprehensive cognitive assessment. Sleep was measured via the Pittsburgh Sleep Quality Index (PSQI), and both sleep and physical activity were measured using 24-h actigraphy for 7 days.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Moderate-to-vigorous physical activity (MVPA) accumulated in at least 10-min bouts moderated the association between self-reported sleep efficiency and episodic memory, processing speed, executive function (EF)/attentional control, and working memory (β<sub>[range]</sub> = −0.10 to −0.17, all <i>p </i>< 0.05). In addition, light-intensity physical activity moderated the association of actigraphy-measured wake after sleep onset (WASO) with EF/attentional control and processing speed (β<sub>s</sub> = 0.10, all <i>p</i> < 0.05). The direction of these results was such that lower sleep efficiency and greater WASO was associated with poorer cognitive performance, but this association was attenuated by engaging in greater amounts of physical activity.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>These results support the hypothesis that physical activity may mitigate the association between poor sleep and cognitive deficits in older adulthood. We highlight the need for further longitudinal studies and randomized clinical trials of exercise to further examine these associations. These results suggest that even small amounts of MVPA or light intensity physical activity mitigate the association between poor sleep and cognitive deficits in older adulthood.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Moderate-to-vigorous physical activity moderated the association of self-reported sleep efficiency with cognition.</li>\n \n <li>Light physical activity moderated the association of wake after sleep onset with cognition.</li>\n \n <li>Physical activity may mitigate sleep-related cognitive deficits in older adults.</li>\n \n <li>Further longitudinal studies and randomized controlled trials are needed.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 2","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70110","citationCount":"0","resultStr":"{\"title\":\"Physical activity may mitigate sleep-related cognitive deficits in older adults: Findings from the IGNITE study\",\"authors\":\"Kelsey R. 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This study examined whether greater engagement in physical activity moderates the association between sleep and cognitive function in older adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODOLOGY</h3>\\n \\n <p>We utilized baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study. Cognitively unimpaired older adults (<i>n</i> = 589, mean age ± SD: 69.8 ± 3.7, 70% female) underwent a comprehensive cognitive assessment. Sleep was measured via the Pittsburgh Sleep Quality Index (PSQI), and both sleep and physical activity were measured using 24-h actigraphy for 7 days.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Moderate-to-vigorous physical activity (MVPA) accumulated in at least 10-min bouts moderated the association between self-reported sleep efficiency and episodic memory, processing speed, executive function (EF)/attentional control, and working memory (β<sub>[range]</sub> = −0.10 to −0.17, all <i>p </i>< 0.05). In addition, light-intensity physical activity moderated the association of actigraphy-measured wake after sleep onset (WASO) with EF/attentional control and processing speed (β<sub>s</sub> = 0.10, all <i>p</i> < 0.05). The direction of these results was such that lower sleep efficiency and greater WASO was associated with poorer cognitive performance, but this association was attenuated by engaging in greater amounts of physical activity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>These results support the hypothesis that physical activity may mitigate the association between poor sleep and cognitive deficits in older adulthood. We highlight the need for further longitudinal studies and randomized clinical trials of exercise to further examine these associations. These results suggest that even small amounts of MVPA or light intensity physical activity mitigate the association between poor sleep and cognitive deficits in older adulthood.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Moderate-to-vigorous physical activity moderated the association of self-reported sleep efficiency with cognition.</li>\\n \\n <li>Light physical activity moderated the association of wake after sleep onset with cognition.</li>\\n \\n <li>Physical activity may mitigate sleep-related cognitive deficits in older adults.</li>\\n \\n <li>Further longitudinal studies and randomized controlled trials are needed.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":53225,\"journal\":{\"name\":\"Alzheimer''s and Dementia: Translational Research and Clinical Interventions\",\"volume\":\"11 2\",\"pages\":\"\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70110\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer''s and Dementia: Translational Research and Clinical Interventions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/trc2.70110\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/trc2.70110","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Physical activity may mitigate sleep-related cognitive deficits in older adults: Findings from the IGNITE study
INTRODUCTION
Poor sleep is commonly associated with poorer cognition in older adults. Unfortunately, effective sleep improvement therapies for older adults are limited in their accessibility and have shown only subtle effects on cognition. Physical activity, however, is associated with better cognition in older adults and may compensate for cognitive deficits related to poor sleep. This study examined whether greater engagement in physical activity moderates the association between sleep and cognitive function in older adults.
METHODOLOGY
We utilized baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE) study. Cognitively unimpaired older adults (n = 589, mean age ± SD: 69.8 ± 3.7, 70% female) underwent a comprehensive cognitive assessment. Sleep was measured via the Pittsburgh Sleep Quality Index (PSQI), and both sleep and physical activity were measured using 24-h actigraphy for 7 days.
RESULTS
Moderate-to-vigorous physical activity (MVPA) accumulated in at least 10-min bouts moderated the association between self-reported sleep efficiency and episodic memory, processing speed, executive function (EF)/attentional control, and working memory (β[range] = −0.10 to −0.17, all p < 0.05). In addition, light-intensity physical activity moderated the association of actigraphy-measured wake after sleep onset (WASO) with EF/attentional control and processing speed (βs = 0.10, all p < 0.05). The direction of these results was such that lower sleep efficiency and greater WASO was associated with poorer cognitive performance, but this association was attenuated by engaging in greater amounts of physical activity.
DISCUSSION
These results support the hypothesis that physical activity may mitigate the association between poor sleep and cognitive deficits in older adulthood. We highlight the need for further longitudinal studies and randomized clinical trials of exercise to further examine these associations. These results suggest that even small amounts of MVPA or light intensity physical activity mitigate the association between poor sleep and cognitive deficits in older adulthood.
Highlights
Moderate-to-vigorous physical activity moderated the association of self-reported sleep efficiency with cognition.
Light physical activity moderated the association of wake after sleep onset with cognition.
Physical activity may mitigate sleep-related cognitive deficits in older adults.
Further longitudinal studies and randomized controlled trials are needed.
期刊介绍：
Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.
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