秀丽隐杆线虫行为成分的剖析及Omega/Delta匝在趋化性中的作用

IF 1.3 4区 生物学 Q4 CELL BIOLOGY
Genes to Cells Pub Date : 2025-05-29 DOI:10.1111/gtc.70026
Karin Suwazono, Koyo Kuze, Ukyo T. Tazawa, Moon Sun Jang, Hirofumi Kunitomo, Yu Toyoshima, Yuichi Iino
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引用次数: 0

摘要

秀丽隐杆线虫的趋化机制主要由两部分组成:旋转机制和风向标机制。旋转机制是一种旋转运动的形式,它调节被称为旋转的快速重新定向行为的频率,其中包括omega/delta旋转,而风向标机制涉及逐渐的方向调整。此外,先前的研究表明,在旋转中,不仅可以调节重新定向的频率,还可以调节重新定向的角度。然而,传统的基于质心的分析没有解决转弯时的姿势动力学问题。在这项研究中,我们在趋化过程中跟踪了个体蠕虫的运动,并确定了代表蠕虫姿势的中心线。从这些数据中,我们提取了转弯行为,分类了姿势模式,并量化了转弯过程中的方向变化。我们的研究结果表明,在旋转过程中,重新定向的角度是可以调节的,以使动物朝向所需的化学浓度。此外,我们还发现了姿势动力学和方向变化的多样性。对转弯顺序进行了详细的分类,通过选择特定的转弯顺序类型和调整转弯角度来实现定向转弯。这项研究提供了迄今为止最详细和定量的分析转向行为作为秀丽隐杆线虫趋化性的基本组成部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dissection of Behavioral Components and the Role of Omega/Delta Turns for the Chemotaxis of C. elegans

Dissection of Behavioral Components and the Role of Omega/Delta Turns for the Chemotaxis of C. elegans

The chemotactic mechanism of the nematode Caenorhabditis elegans primarily consists of two components: the pirouette mechanism and the weathervane mechanism. The pirouette mechanism is a form of klinokinesis that regulates the frequency of rapid reorientation behaviors called pirouettes, which include omega/delta turns, while the weathervane mechanism involves gradual directional adjustments. Furthermore, previous studies have shown that in pirouettes, not only is the frequency of reorientation regulated, but the reorientation angle is also adjusted. However, conventional centroid-based analyses have left the postural dynamics during turns unresolved. In this study, we tracked the movement of individual worms during chemotaxis and determined the centerlines representing worm postures. From these data, we extracted turning behaviors, classified postural patterns, and quantified directional changes during turns. Our results indicate that the reorientation angle is modulated during turns to orient the animal toward the desired chemical concentrations. Additionally, we found the diversity of postural dynamics and directional changes in turn sequences. A detailed classification of turn sequences revealed that directional turning is achieved by selection of specific sequence types and adjustment of turning angles. This study provides the most detailed and quantitative analysis to date of the turning behaviors as a fundamental component of C. elegans chemotaxis.

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来源期刊
Genes to Cells
Genes to Cells 生物-细胞生物学
CiteScore
3.40
自引率
0.00%
发文量
71
审稿时长
3 months
期刊介绍: Genes to Cells provides an international forum for the publication of papers describing important aspects of molecular and cellular biology. The journal aims to present papers that provide conceptual advance in the relevant field. Particular emphasis will be placed on work aimed at understanding the basic mechanisms underlying biological events.
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