天生杀手：利用NK细胞治疗癌症

IF 2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2025-05-15 DOI:10.1016/j.beha.2025.101630

Kanchi Patell , Katherine Myers , Amr Mohamed , David Wald , J. Eva Selfridge

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引用次数: 0

摘要

过继细胞疗法，或收集和转移免疫细胞给患者，正在成为许多恶性肿瘤的治疗选择，特别是血液恶性肿瘤，在实体瘤和非恶性疾病（如自身免疫性疾病）中发挥越来越大的作用。先天免疫细胞自然杀伤（NK）细胞的过继性转移是一种独特的潜在治疗方法，可以单独治疗癌症患者，也可以作为其他免疫靶向治疗的辅助治疗方法，与其他细胞治疗方法（如T细胞）相比具有一些优势。我们回顾了NK细胞作为人类疾病治疗的关键概念，并讨论了使用NK细胞治疗恶性肿瘤的关键试验。

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Natural born Killers: Harnessing NK cells to treat cancer

Adoptive cellular therapy, or the collection and transfer of immune cells to patients, is emerging as a treatment option for many malignancies, especially hematologic malignancies, with a growing role in solid tumors and non-malignant conditions such as autoimmune diseases. The adoptive transfer of the innate immune cell natural killer (NK) cells is uniquely poised as a potential therapy alone or as an adjunct to other immune-targeted therapies for patients with cancer, with several advantages over other cell therapies such as T cells. We review key concepts in NK cells as a therapy for human disease and discuss key trials using NK cells in malignancy.

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.