管状骨和非管状骨成软骨细胞瘤x线、CT和MRI影像的对比分析

IF 3.4 2区医学 Q2 Medicine

Journal of Bone Oncology Pub Date : 2025-05-28 DOI:10.1016/j.jbo.2025.100691

Xiang Feng , Yuxiang Fang , Hanhua Yu , Zhanqiang Song , Xiangrong Guo , Man Yang

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引用次数: 0

摘要

目的比较分析管状骨与非管状骨成软骨细胞瘤（CB）患者的x线、CT、MRI影像特征，提高术前诊断准确率和术后随访复发率。方法选取2013年8月至2024年3月在我院及华中科技大学同济医学院附属协和医院经手术病理证实的肺结核患者61例。回顾性收集并分析其临床、影像及病理资料。临床资料包括年龄和性别。影像资料包括病灶大小、分叶、膨胀性、骨嵴、钙化、硬化边缘、骨膜反应、软组织肿胀、液面和动脉瘤性骨囊肿（ABC）。病理资料包括病理结果和免疫组化（IHC）。结果管状骨组和非管状骨组的平均发病年龄分别为17.3±5.5岁和25.6±5.7岁（p = 0.00）。管状骨组和非管状骨组的胸廓扩张率分别为37%、63%、69%和31% (p = 0.01)，胸廓扩张率分别为46%、54%、77%和20% (p = 0.01)，液面扩张率分别为17%、83%、62%和38% （p = 0.00）。病变小于12个月的CB主要是非钙化或斑驳钙化，病变大于12个月的CB主要为斑片状或浑浊钙化。跟骨和距骨的骨量占非管状骨骨量的54%。术前恶性病变1例，术后复发1例。结论CB患者非管状骨病变肿胀，易形成粗骨嵴和液面，合并ABC时骨肿胀更为明显。CB患者恶性转化和术后复发的可能性较低。

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Comparative analysis of X-ray, CT, and MRI images in patients with chondroblastoma in tubular and non-tubular bones

Objective

To compare and analyze the image features of X-ray, computerized tomography (CT), and magnetic resonance imaging (MRI) in patients with chondroblastoma (CB) in tubular and non-tubular bones, to improve the preoperative diagnostic accuracy and follow-up the postoperative recurrence rate.

Methods

Sixty-one CB patients confirmed by surgical pathology in our hospital and Huazhong University of Science and Technology Tongji Medical College Affiliated Union Hospital from August 2013 to March 2024 were included in this study. Their clinical, image, and pathological data were retrospectively collected and analyzed. Clinical data included age and gender. Image data included lesion size, lobulation, distensibility, bone crest, calcification, sclerotic margin, periosteal reaction, soft tissue swelling, fluid level, and aneurysmal bone cyst (ABC). Pathologic data included pathological findings and immunohistochemistry (IHC).

Results

The average onset age in tubular bone and non-tubular bone groups was 17.3 ± 5.5 and 25.6 ± 5.7 respectively (p = 0.00). The percentage of distensibility with or without was 37 %, 63 %, 69 % and 31 % (p = 0.01), the percentage of bone crest with or without was 46 %, 54 %, 77 % and 20 % (p = 0.01), and the percentage of fluid level with or without was 17 %, 83 %, 62 % and 38 % in tubular bone and non-tubular bone groups, respectively (p = 0.00). CB was predominantly non-calcified or mottled calcification in patients with lesions less than 12 months and patchy or cloudy calcification in patients with lesions more than 12 months. CB of the calcaneus and talus accounted for 54 % of the CB of the non-tubular bones. There was one case of preoperative malignant lesion and one case of postoperative recurrence.

Conclusion

Lesions in CB patients in non-tubular bone are swollen and are prone to form a coarse bone creast and fluid level, and the bone swells even more obviously when CB is combined with ABC. There is a low possibility of malignant transformation and postoperative recurrence in CB patients.

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来源期刊

Journal of Bone Oncology ONCOLOGY-

CiteScore

7.20

自引率

2.90%

发文量

审稿时长

34 days

期刊介绍： The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.